Background: The induction of de novo CD8(+) T-cell responses is essential for protective antiviral immunity, but this process is often impaired in people with HIV-1 (PWH). We investigated the extent to which the immune competence of naive CD8(+) T cells, a key determinant of priming ...
In this study, we generated this enhanced priming wave through whole CD4+ T cell compartment depletion with an ɑCD4 depleting antibody, Treg-specific ablation using Foxp3-DTR mice, or treatment with ɑCTLA-4, a modality known to increase priming. These combinations resulted in high levels of ...
CD8(+) T-cell priming and boosting: more antigen-presenting DC, or more antigen per DC? RNA transfection is a standard method to load dendritic cells (DC) with antigen for therapeutic cancer vaccination. While electroporation yields high trans... N Schaft,V Wellner,Christian Wohn… - 《Cancer...
Stager S, Kaye PM (2004) CD8+ T-cell priming regulated by cytokines of the innate immune system. Trends Mol Med 10(8):366–371... Simona Stger,PM Kaye - 《Trends in Molecular Medicine》 被引量: 38发表: 2004年 CD8+ T-cell priming regulated by cytokines of the innate immune system...
T cells in proximity of aged DRG neurons expressing MHC-I. CD8 T cells repress axonal regeneration of sensory DRG neurons by inhibiting the regenerative signals pAKT and pS6 via caspase 3 activation. Remarkably, CXCL13 neutralization withmonoclonal antibodiesprevents CXCR5+ CD8+ T cell recruitment ...
Crosstalk between the peripheral immune system and TME is crucial for the antitumor responses of effector CD8+ T cells. Therefore, the proper understanding of peripheral and tumorinfiltrating T cells is crucial from a therapeutic perspective. The priming, expansion, and migration of T cells specific...
Compared with DCs matured with LPS or R848 alone, the DC population matured with both adjuvants primed CD8+ T-cell responses containing an increased proportion of antigen-specific T cells retaining CD28 expression. Priming with a homogenous subpopulation of LPS/R848-matured DCs that were CD83(Hi...
ARTICLES Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes Heather D Hickman1, Kazuyo Takeda1, Cara N Skon1, Faith R Murray1, Scott E Hensley1, Joshua Loomis2, Glen N Barber2, Jack R Bennink1 & Jonathan W Yewdell1 It is uncertain how ...
Cross-primingMHCVirusTumor"Cross-priming" refers to the activation of naive CD8+ T cells by antigen-presenting cells that have acquired nominal antigens from another cell. The biological relevance of cross-priming of CD8+ T cells has recently been challenged (Zinkernagel, R. M., Eur. J. ...
体内实验显示,缺失CASP9减缓了肿瘤细胞在野生小鼠体内的生长,放疗可进一步控制CASP9缺失的肿瘤细胞的生长甚至完全清除。机理研究显示,放射治疗诱导CASP9缺失的肿瘤细胞产生的I型干扰素,能够促进树突细胞的交叉致敏 (cross-priming) 功能,从而诱导并增强肿瘤特异性CD8+ T细胞的功能。