Fig. 2: αCD4 leads to new wave of CD8+ T cell priming, and Tx supports cytotoxicity of these cells in the tumor. a, b Flow cytometry quantification (mean ± SD) of CD4+ T cells (gated on single cell/live/CD45+/CD3+NK1.1−/CD4+) and Tregs (gated on single cell/live/...
Background: The induction of de novo CD8(+) T-cell responses is essential for protective antiviral immunity, but this process is often impaired in people with HIV-1 (PWH). We investigated the extent to which the immune competence of naive CD8(+) T cells, a key determinant of priming ...
WT or CXCR5-/- CD8+ T cells were isolated and adoptively transferred to the young and aged OT-I Rag-/- mice, which are B/T cell deficient, and mice were sacrificed 3 days after nerve injury.The results showed a robust infiltration of adoptively transferred...
CD8+ T-cell priming regulated by cytokines of the innate immune system. Trends Mol. Med. 10 : 366-371.Stager S, Kaye PM. CD8+ T-cell priming ... Simona Stger,PM Kaye - 《Trends in Molecular Medicine》 被引量: 38发表: 2004年 CD8+ T-cell priming regulated by cytokines of the inn...
CD8(+) T-cell priming and boosting: more antigen-presenting DC, or more antigen per DC? RNA transfection is a standard method to load dendritic cells (DC) with antigen for therapeutic cancer vaccination. While electroporation yields high trans... N Schaft,V Wellner,Christian Wohn… - 《Cancer...
Compared with DCs matured with LPS or R848 alone, the DC population matured with both adjuvants primed CD8+ T-cell responses containing an increased proportion of antigen-specific T cells retaining CD28 expression. Priming with a homogenous subpopulation of LPS/R848-matured DCs that were CD83(Hi...
美国圣裘德儿童研究医院Ben Youngblood课题组发表了题为Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes的文章。该研究探讨了1型糖尿病(T1D)中的β细胞特异性CD8+ T细胞的长寿命机制。该团队建立了一个基于DNA甲基化分析的多能性指数系统,分析发现...
IL-2 signaling:T细胞激活过程中的增殖、功能作用[effector、memory T都需要];调控effector-memory反应;Treg的产生与维持。但是在naive CD8+T的priming中不怎么关键 IL-2Rα含有2个sushi domains (SD),为与IL-2结合所必需 SUSD2:单次I型跨膜蛋白,C端有SD结构域。胞质段很短,可能不能直接产生下游信号。该文...
Crosstalk between the peripheral immune system and TME is crucial for the antitumor responses of effector CD8+ T cells. Therefore, the proper understanding of peripheral and tumorinfiltrating T cells is crucial from a therapeutic perspective. The priming, expansion, and migration of T cells specific...
First, after viral infection, CD8+ T cell priming occurred in a thin, nearly sessile layer just beneath the SCS. SCS macrophages form a nonmotile layer of cells that often penetrate the SCS lining cells, thereby gaining access to lymph deposited in the sinus12,27,28. SCS macrophages have ...