Marlyn MayoUniversity of Texas Southwestern Medical Center Dallas TXJohn Wiley & Sons, LtdClinical Liver DiseaseLindor KD, Bowlus CL, Boyer J. Primary biliary cholangitis: 2018 practice guidance from the American Association for the Study of Liver Diseases. Hepatology 2019;138:394-419....
Primary biliary cholangitis (PBC) is an autoimmune liver disorder characterized by progressive destruction of intrahepatic bile ducts, leading to cholestasis, cirrhosis, and liver failure. The etiology of PBC is unknown; however a complex interaction between genetic, environmental, and autoimmune factors ...
Ludwig J, Dickson ER, McDonald GS. Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virchows Arch A Pathol Anat Histol. 1978;379:103–12. ArticleCASPubMedGoogle Scholar Nakanuma Y, Ohta G, Takeshita H, et al. Florid duct lesions and extensive ...
Initially primary sclerosing cholangitis may be asymptomatic if the flow of bile is not significantly impeded. This asymptomatic phase can be as long as 10 years in some cases. Gradually symptoms become apparent. However, at the outset the symptoms may be vague and not attributed to the biliary...
Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis Article Open access 24 February 2023 Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization Article Open access...
We aimed at characterizing the clinical presentation and prognosis of cholangiocarcinoma in youth with and without primary sclerosing cholangitis (PSC).Thirteen patients < or =25 yr of age with cholangiocarcinoma with or without PSC seen at the Mayo Clinic in Rochester, MN from 1980 to 2005 were ...
(1993) Immunohistochemical characteriza- tion of hepatic lymphocytes in primary biliary cirrhosis in compar- ison with primary sclerosing cholangitis and ... E Hashimoto,KD Lindor,HA Homburger,... - 《Mayo Clinic Proceedings》 被引量: 664发表: 1993年 Distinct clinicopathological entity 'autoimmune pa...
Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation1,2,3. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs geno...
Approximately 5% to 10% of patients with features otherwise consistent with primary biliary cirrhosis (PBC) lack antimitochondrial antibodies (AMA). Most of these patients have other autoantibodies, a syndrome recently named “autoimmune cholangitis.” We report our experience in patients with AMA-...
Primary sclerosing cholangitis is a chronic and intractably progressive cholangiopathy that leads to the development of fibrotic biliary strictures, cholangitis, biliary cirrhosis and end-stage liver disease. It portends a significant risk of hepatobiliary and colorectal malignancy. The disease is intimatel...