Preprotein translocase subunit SecG (secG); modulator for HflB protease specific for phage λ-cII repressor (hflK; hflC; hflKC)In vitro studies suggest that molecules targeting bacterial membrane proteins secG and hflKC could improve the therapeutic index of aminoglycoside antibiotics. Further details...
In the first step of translocation, preproteins are targeted for binding to their 2-site receptor SecA, the peripheral ATPase subunit of the translocase. We now reveal that secretory preproteins use a dual-key mechanism to bridge the signal peptide and mature domain receptor sites and ...
SecA, the peripheral subunit of E. coli preprotein translocase, alternates between a membrane inserted and a deinserted state as part of the catalytic cycl... A Economou,W Wickner - 《Cell》 被引量: 959发表: 1994年 The purified E. coli integral membrane protein SecY/E is sufficient for...
Duong F, Wickner W (1997) Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme . EMBO J 16 : 2756–2768Duong,F. and Wickner,W. (1997a) Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase ...
Preproteins bind to translocase and trigger cycles of ATP binding and hydrolysis that drive a transition of SecA between two distinct conformational states. These changes are transmitted to SecG and lead to inversion of its membrane topology. SecA conformational changes promote directed migration of ...