AIM: To obtain the short peptides mimic antigenic epitopes selected by rat natural antibodies to schistosomes, and to explore their immunoprotection agains... M Wang,XY Yi,XP Li,... - 《World Journal of Gastroenterology》 被引量: 36发表: 2005年 Designing and Using Site-Specific Antibodies to...
Prediction of the binding ability of antigenic peptides to MHC class II molecules is more complex that for class I. Class II molecules bind to peptides of different lengths and the core region that interacts with the binding site on the class II MHC molecule is located anywhere within the ...
Modelling the interaction between potentially antigenic peptides and Major Histocompatibility Complex (MHC) molecules is a key step in identifying potential T-cell epitopes. For Class II MHC alleles, the binding groove is open at both ends, causing ambiguity in the positional alignment between the gr...
Detecting MHC class I allele HLA-B*2705 binding peptides can reduce the number of peptides that need to be tested experimentally. This work describes the implementation of SVM algorithm, developed for the identification of HLA-B*2705 binding peptides in antigenic sequences. The specificity and ...
neoantigens from tumoral RNA sequencing reads. The developed software can estimate H-2 peptide ligands, with an AUC comparable or superior to state-of-the-art methods, directly from tumor samples. As a proof-of-concept, we used the B16 melanoma model to test the system’s predictive ...
Here, epitope refers to the predicted region of the antigenic protein recognized by the antibody’s paratope. The structure of S protein bound to a neutralizing antibody (24, 25) provided the starting point for 12 of these antibody epitopes. Epitopes were designed to potentially isolate even ...
Antigens presented on the cell surface have been subjected to multiple biological processes. Among them, C-terminal antigen processing constitutes one of the main bottlenecks of the peptide presentation pathways, as it delimits the peptidome that will be subjected downstream. Here, we present NetClea...
3D structure of proteins, and other information [18]. As the explosive growth of sequence data, more and more researchers have moved toward sequence data based approaches to predict PPIs. Experimental results show that it is adequate to predict new PPIs using amino acid sequences alone [19–27...
5H). C1 and C2 with chronic antigenic exposure were both the infiltrated-inflamed type (so-called ‘hot’ tumors) as their TMEs were enriched in CTLs. C2 tumors (highly immunosuppressive, high ISP) displayed a more prominent terminally CD8+ Tex phenotype, while C1 (low ISP) was observed ...
A method is presented for predicting the folded structure of proteins that comprises obtaining an alignment of the sequences of a set of homologous proteins, using patterns of conservation and variati