Binding ability prediction of antigen peptides to MHC class molecules isimportant in vaccine development, We also found the SVM based MHCII-IAb peptide regions, 40- YALADRAEK,10- ISLAVALAT, 99- MYQAERALE, 14- VALATWPSE, (optimal score is 1.494); MHCII-IAd peptide regions, 96-LDIMYQAER...
Ciulli S, Galletti E, Battilani M, Galligioni V, Prosperi S. Analysis of variability and antigenic peptide prediction of E2 BVDV glycoprotein in a mucosal- disease affected animal. Vet Res Commun 2009;33(Suppl. 1):125e7.Ciulli, S., E. Galletti, et al. (2009). Analysis of variability...
The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of...
The prediction of BetaWrap motifs of the reference genome structural proteins, variant proteins, and the proteins that have a signal peptide was carried out by BetaWrap online server (http://cb.csail.mit.edu/cb/betawrap/betawrap.html)54. Prediction of similarity with host proteome The reference...
A crucial step in designing of peptide vaccines involves the identification of B-cell epitopes. In past, numerous methods have been developed for predicting continuous B-cell epitopes, most of these methods are based on physico-chemical properties of amino acids. Presently, its difficult to say wh...
MAPPP is a bioinformatics tool for the prediction of potential antigenic epitopes presented on the cell surface by major histocompatibility complex class I (MHC I) molecules to CD8 positive T lymphocytes. It combines existing predictions for proteasomal cleavage with peptide anchoring to MHC I molecule...
The second included the same fragment (TLIA) plus the peptide flanking regions of P10 based on the 9-mer core prediction (see Section 2.2.1), which were found useful for multiple-allele MHC II peptide engineering [31]. After selecting the two sets of positions, we performed two different ...
In order to get evidence regarding the formation of P10 or P10-like peptides by proteolysis of gp43, we took advantage of in-silico tools for prediction of protease cleavage products (Table1). We agree that this is a first approach to gain insight into the formation of these peptides, si...
(Fig.1b). We thus went on to fine map the epitope of F12 on intact 229E S trimer and to characterize its breadth within genus. In the presence of F12, decreased HDX was observed for peptides 974–983 aa, 1000–1007 aa, 1000–1008 aa, 1027–1033 aa and 1029–1033 aa in 229E ...
the immune mechanisms induced by antigen epitopes and the latest advances in identifyingT. gondiiantigen epitopes. Particular attention was paid to the potential clinical usefulness of epitopes in this context. Through a critical analysis of the current state of knowledge, we elucidated the latest ...