The potential of preclinical models to anticipate treatment efficacy and clinical benefit is also presented, using examples in different tumor types. Introduction Genomic driven precision medicine approaches are transforming the field of oncology [[1], [2], [3], [4]]. The advent of high ...
Corrigendum to Preclinical models for precision oncology. BBACAN 1870/2 (2018) 239–246 Hepatocellular carcinoma (HCC) is a complex heterogeneous disease with high morbidity and mortality. Recent progress in molecular targeted drugs including ... M Ibarrola-Villava,A Cervantes,A Bardelli - Biochimica...
Therefore, this approach is suitable for mod- elling genetically-defined cholangiocarcinogenesis in bipotent liver precursors and generating models for precision oncology research12. Based on the available data and unanimous agreement, the expert panel strongly suggests (Box 1): the use of a ...
As a heterogeneous disease, the research of OC requires preclinical models that are personalized to solve individual issues, and OC cell lines, as discussed previously, are clearly not up to it. Recently, the NCI decided to take up with PDXs for drug screening as a substitution for the NCI-...
Additive biomanufacturing, including 3D bioprinting, also offers a cost-effective and user-friendly approach to generating complex 3D in vitro models for cancer research and drug screening with high precision, reproducibility, and control over microarchitecture, which in turn allows for the replication ...
Optimizing mouse models for precision cancer prevention. Nat. Rev. Cancer 16, 187–196 (2016). Article CAS PubMed PubMed Central Google Scholar Kersten, K., de Visser, K. E., van Miltenburg, M. H. & Jonkers, J. Genetically engineered mouse models in oncology research and cancer ...
Despite their value, these in vivo models are costly, labor-intensive, and time-consuming. Recently, patient-derived lung cancer organoids (LCOs) have emerged as a promising in vitro tool for functional precision oncology studies. These LCOs demonstrate high success rates in growth and maintenance...
and accelerate drug and biologics R&D programs. The cutting-edge agenda includes innovation in predictive animal models for precision oncology and immuno-oncology, 3D and iPS cell models for drug discovery and screening, disease modeling and artificial intelligence in translational research, and strategies...
and accelerate drug and biologics R&D programs. The cutting-edge agenda includes innovation in predictive animal models for precision oncology and immuno-oncology, 3D and iPS cell models for drug discovery and screening, disease modeling and artificial intelligence in translational research, and strategies...
Boost your pipeline with fully human antibodies and integrated drug discovery services using humanized animal models, gene-editing, and efficacy testing.