Precision medicine strategies in oncology: mixed approaches to matched therapies.In the last few decades, precision medicine aroused in oncology as a promising approach to treat patients with molecularly targeted agents, developed to specifically inhibit an abnormally activated molecular target in a ...
The OncLive Precision Medicine in Oncology® condition center page is a comprehensive resource for clinical news and expert insights on precision-focused approaches in patients with cancer, with gene-targeted tyrosine kinase inhibitors and antibody-drug conjugates, checkpoint inhibitors, tumor-infiltrating...
Precision medicine in pediatric oncology: Lessons learned and next steps The maturation of genomic technologies has enabled new discoveries in disease pathogenesis as well as new approaches to patient care. In pediatric oncology... RJ Mody,JR Prensner,J Everett,... - 《Pediatric Blood & Cancer》...
Here, AI combined with multiple different combinations of CpG markers, statistical and bioinformatic approaches yielded high diagnostic accuracy for OC detection with an AUC close to or equal to 1.0. Despite the small number of cases in the study statistical significance was achieved with the lower ...
Rather, it falls to the drug manufacturers to market the use of targeted therapeutics in specific clinical settings and to molecular diagnostic companies to advertise approvals of their platforms by the FDA as options for tumor agnostic approaches to disease management. A potential magnitude of ...
Until recently the application of artificial intelligence (AI) in precision oncology was confined to activities in drug development and had limited impact on the personalisation of therapy. Now, a number of approaches have been proposed for the personalisation of drug and cell therapies with AI appli...
In his January 2015 State of the Union address, President Barack Obama announced a new Precision Medicine Initiative (PMI) to personalize approaches toward improving health and treating disease (www.whitehouse.gov/precision-medicine). He... JE Fradkin,MC Hanlon,GP Rodgers - 《Diabetes Care》 被...
in clinical trials. From a commercial perspective, efficient approaches are required to optimize drug access and adoption, while achieving the aspiration to leave no patient behind requires precision. Large-scale commercial tactics are unaffordable in the majority of rare-cancer indicatio...
Novel approaches to modulate the immune microenvironment Oncolytic viriotherapy Oncolytic viruses have been studied to induce direct anti-tumor effects as well as promote immune activation and immune-related oncolytic activity (Fig.2). Fig. 2: Selected immunomodulatory therapies currently in clinical devel...
The concept of precision oncology involves the prescription of therapies that target the molecular driver alterations of an individual patient’s tumor. This treatment paradigm has been accelerated in recent years through increasing integration of molecular profiling approaches into mainstream clinical oncology...