Radiation Oncology201914:150 MethodologyPublished on:22 August 2019 Full Text PDF 18F-FDG-PET-based Radiomics signature predicts MGMT promoter methylation status in primary diffuse glioma The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter has emerged as a favorable indepen...
Bell EH, Zhang P, Shaw EG et al (2020) Comprehensive Genomic Analysis in NRG Oncology/RTOG 9802: a phase III trial of Radiation Versus Radiation Plus Procarbazine, Lomustine (CCNU), and Vincristine in High-Risk Low-Grade Glioma. J Clin Oncol 38:3407–3417 CASPubMedPubMed CentralGoogle Sc...
Image segmentation involves partitioning an image into meaningful regions, which is essential for accurately identifying tumors and organs at risk in radiation oncology. Accurate segmentation is crucial for treatment planning, as it directly impacts the precision of radiation delivery. Traditional manual seg...
et al. The complex relationship between lung tumor volume and survival in patients with non-small cell lung cancer treated by definitive radiotherapy: a prospective, observational prognostic factor study of the Trans-Tasman Radiation Oncology Group (TROG 99.05). Radiother. Oncol. 106, 305–311 (...
models in radiation therapy have been developed by the European Society for Therapeutic Radiation Oncology and the American Association of Physics in Medicine for the standardization of this approach94. Investigators used statistics and ML (Least Absolute Shrinkage and Selection Operator) to develop a ...
2022npj Precision Oncology doi:10.1038/s41698-022-00254-ypmid:35228642 Patients with advanced anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer who are prescribed ALK-tyrosine kinase inhibitors (ALK-TKIs) rarely have complete responses, with residual tumors relapsing as heterogeneous...
In particular, AI is on the rise in drug discovery and development. While advocates highlight the potential that these tools bring. Detractors, instead, adopt a more cautious approach, seeking solid evidence on the impact on drug discovery initiatives [9]. ...
The major concern is whether germline mutations will increase radiation toxicity or not. The American Society for Radiation Oncology (ASTRO) re- cently held a workshop to address this issue [74]. As previously known, bi-allelic pathological mutations at certain DNA repair genes, such as those ...
Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. Cancer 117, 4623–4632 (2011). Article CAS PubMed Google Scholar Scartozzi, M. et al. Epidermal growth factor receptor (EGFR) status in primary colorectal ...
Since Nrf2 functions as a transcription factor, we assessed the protein expression of Nrf2 and PHKG2 in the whole tissue and the nuclear expression of Nrf2. Western blot results revealed that both whole and nuclear Nrf2 exhibited low expression levels in radiation-sensitive tissues, while PHKG2 ...