Since the discovery of nerve growth factor, there has been accumulating evidence that neurotrophins (NTs) mediate various biological responses of peripheral and central neurons. NTs have been traditionally studied as the regulating factors of neuronal survival and differentiation. Recent data indicate that...
PET study of the pre- and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington's disease. PET and: markers for the pre- and postsynaptic neurons were used to study the system in vivo in . The radioligands used were 23390 for D1-receptors, []racl... N Ginova...
Pharmacological properties of pre- and postsynaptic GABAB receptors were compared in CA1 hippocampal pyramidal neurons in vitro. The postsynaptic effects mediated by GABAB receptors, i.e., the baclofen-induced hyperpolarization, the bicuculline-resistant GABA response, and the slow inhibitory postsynaptic ...
With electron microscopy, mGluR1α immunoreactivity was seen in neuronal cell body and dendrites in lamina II of the dorsal horn. In the lateral and ventral horns, only dendrites of neurons were mGluR1α immunopositive. Some mGluR2/3 immunopositive dendrites were demonstrated in lamina II of ...
Gilmor ML, Erickson JD, Varoqui H, Hersh LB, Bennett DA, Cochran EJ, Mufson EJ, Levey AI (1999) Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer’s disease. J ...
The purpose of the present study was to determine the plasticity of pre- and postsynaptic α2-adrenoceptors in the control of spinal glutamatergic synaptic transmission in painful diabetic neuropathy. Whole-cell voltage-clamp recordings of lamina II neurons were performed in sp...
Adrenoceptor-Mediated Post- and Pre-Synaptic Regulations of the Reticulospinal Neurons in Rat Caudal Pontine Reticular Nucleus Here, after demonstrating the expression of α1- and α2-adrenoceptors in the PnC, we found that noradrenaline elicited a post-synaptic effect (inward ... N Yang,QC Qiao...
www.nature.com/scientificreports OPEN Calretinin‑expressing islet cells are a source of pre‑ and post‑synaptic inhibition of non‑peptidergic nociceptor input to the mouse spinal cord Olivia C. Davis 1,7, Allen C. Dickie 1,7, Marami B. Mustapa 1,...
side of the trigeminal ganglion and in the peripherin-positive terminal, respectively, for the first 2 weeks, while outward-directed K+–Cl− cotransporter (KCC2) mRNA and protein were downregulated in secondary relay neurons on the injured side of the spinal trigeminal nucleus caudalis (Sp5C...
Synapses, specialized contact sites between neurons, are the fundamental elements of neuronal information transfer.Synaptic plasticityinvolves changes in synaptic morphology and the number ofneurotransmitter receptors, and is thought to underlie learning and memory. However, it is not clear how these struct...