The pre- and postsynaptic actions of exogenously applied ATP were investigated in intact and dissociated parasympathetic neurones of rat submandibular ganglia. Nerve-evoked excitatory postsynaptic potentials (EPSPs) were not inhibited by the purinergic receptor antagonists, suramin and pyridoxal-phosphate-6...
We showed how eugenol blocks the synaptic transmission and gave a possible interpretation how it inhibits the excitation-contraction coupling that several authors described previously. Eugenol acts both in the pre- and postsynaptic side of the neurons. It blocks the Ca2+-currents, decreases the membra...
Chemical synapses, which consist of presynaptic and postsynaptic compartments as well as a synaptic cleft, employ a multitude of exquisitely arranged and coordinated proteins to convert electrical into chemical signals, and vice versa. The rate and efficacy ofsynaptic transmissionvaries amongsynapses, and...
However, these sensors are usually expressed throughout the neuron and do not report localized calcium signals. Pech et al. generated calcium sensors that are targeted to pre- or postsynaptic compartments in Drosophila. The researchers fused the calcium sensor GCaMP3 either to the postsynaptically ...
Single-unit microelectrode studies were conducted to test the effects of systemic cocaine HCl on spontaneously firing single noradrenergic locus ceruleus (presynaptic) and cerebellar Purkinje (postsynaptic) neurons in rats in vivo. The spontaneous neuronal activity of all locus ceruleus neurons was inhibite...
Bellingham, M.C., Pre- and postsynaptic mechanisms underlying inhibition of hypoglossal motor neuron excitability by riluzole. J Neurophysiol, 2013. 110(5): p. 1047-61.Bellingham, M.C.: Pre- and postsynaptic mechanisms underlying inhibition of hypoglossal motor neuron excitability by riluzole. J ...
Location-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites Cortical computations are critically dependent on interactions between pyramidal neurons (PNs) and a menagerie of inhibitory interneuron types. A key featu... M Jadi,A Polsky,J Schiller,... - 《Plos Computational...
Noradrenergic neuronesDopaminergic neuronesPresynaptic receptorsEvidence suggesting the involvement of specific soma-dendritic, presynaptic, and postsynaptic receptors in central noradrenergic and dopaminergic transmission is discussed.doi:10.1007/BF00587772Klaus Starke...
RanBP9OverexpressionAcceleratesLossofPreand PostsynapticProteinsintheAPDE9TransgenicMouse Brain HongjieWang 1. ,RuizhiWang 1. ,ShaohuaXu 2 ,MadepalliK.Lakshmana 1 * 1SectionofNeurobiology,TorreyPinesInstituteforMolecularStudies,PortSaintLucie,Florida,UnitedStatesofAmerica,2DepartmentofBiologicalSciences,Florida...
Pre- and post-synaptic changes in the expression and distribution of synaptic proteins and mRNA transcripts. a Schematic overview of the pre- and postsynaptic compartment showing differentially expressed genes (DEGs) related to ‘glutamatergic synapse’ and reduced in C9-ALS/FTD (C9) neurons (in re...