Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator required for gene silencing during development. Although PRC2 is a well-established RNA-binding complex, the biological function of PRC2-RNA interaction has been controversial. Here, we study the gene-regulatory role of the inhibitory...
Liu X, Zhou S, Wang W, Ye Y, Zhao Y, Xu Q, Zhou C, Tan F, Cheng S, and Zhou D-X*. Regulation of Histone Methylation and Reprogramming of Gene Expression in the Rice Inflorescence Meristem. The Plant Cell, 2015, 27(5): 4725–4736. Li T, Chen X,Zhong X, Zhao Y, Liu X, ...
Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex involved in the regulation of gene expression in metazoans. PRC2 is formed by a tetrameric core that endows the complex with histone methyltransferase activity, allowing it to mono-, di- and tri-methylate histone H3 ...
Gisele O.L.Rodrigues, ...Scott K.Durum, inAdvances in Biological Regulation, 2021 11PRC complexes (PRC1: AUTS2); (PRC2: EZH2, SUZ12, and EED) Polycomb repressive complexes (PRC) are chromatin repressor complexes that regulate gene expression across many developmental pathways. There are two...
Summary Polycomb-repressive complex 1 (PRC1) has a central role in the regulation of heritable gene silencing during differentiation and development. PRC1 ... Tavares,L.,Dimitrova,... - CELL -CAMBRIDGE MA- 被引量: 506发表: 2012年 Jarid2 is a PRC2 component in embryonic stem cells require...
Removal of this repressive chromatin modification results in marked up-regulation in gene expression, the consequence of which is a shift in the balance between self-renewal and differentiation toward differentiation, both directly to neurons and indirectly via basal progenitor cell genesis. Although the...
Polycomb group proteins (PcG) are required for proper developmental regulation and cell fate commitment in metazoans. Recently, four studies reported the identification of JARID2, a JmjC domain-containing protein, as a component of the Polycomb-repressive complex 2 (PRC2), which is involved in im...
To test the specificity of EBdCas9, we monitored POU5F1 (OCT4) gene expression and observed no significant changes in OCT4 in cells treated with gRNAs targeting the TBX18 promoter (Figure 1J); hence, TBX18 upregulation is not a secondary effect of cellular differentiation. Assay for ...
The hierarchical organization of eukaryotic chromatin plays a central role in gene regulation, by controlling the extent to which the transcription machinery can access DNA. The histone variants H3.3 and H2A.Z have recently been identified as key regulat
DiCroce,L.,andHelin,K.(2013).TranscriptionalregulationbyPolycombgroupproteins.Nat.Struct.Mol.Biol.20,1147-1155.ThisrecentreviewgiveagreatlookmoreofthelesserknownattributesofthePcGproteins.ThisreviewisforareaderwhoknownaboutwhatPcGproteinsare,butwantssomemoredetailedinformationonsomekeycomponents.Sauvageau,M.,...