Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator required for gene silencing during development. Although PRC2 is a well-established RNA-binding complex, the biological function of PRC2-RNA interaction has been controversial. Here, we study the gene-regulatory role of the inhibitory...
Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex involved in the regulation of gene expression in metazoans. PRC2 is formed by a tetrameric core that endows the complex with histone methyltransferase activity, allowing it to mono-, di- and tri-methylate histone H3 ...
In addition to the well-documented defects in embryonic viability upon down-regulation of Jarid2, ES cell differentiation is impaired, as is Oct4 silencing. 展开 关键词:Polycomb chromatin Histone methylation Jarid2 DOI: 10.1101/gad.1886410 被引量: 784 ...
Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex involved in the regulation of gene expression in metazoans. PRC2 is formed by a tetrameric core that endows the complex with histone methyltransferase activity, allowing it to mono-, di- and tri-methylate histone H3 ...
Gisele O.L.Rodrigues, ...Scott K.Durum, inAdvances in Biological Regulation, 2021 11PRC complexes (PRC1: AUTS2); (PRC2: EZH2, SUZ12, and EED) Polycomb repressive complexes (PRC) are chromatinrepressorcomplexes that regulate gene expression across many developmental pathways. There are two dis...
Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) cooperate to determine cell identity by epigenetic gene expression regulation. However, the mechanism of PRC2 recruitment by means of recognition of PRC1-mediated H2AK119ub1 remains poorly understood. Our PRC2 cryo–electron microscopy structure...
Liu X, Zhou S, Wang W, Ye Y, Zhao Y, Xu Q, Zhou C, Tan F, Cheng S, and Zhou D-X*. Regulation of Histone Methylation and Reprogramming of Gene Expression in the Rice Inflorescence Meristem. The Plant Cell, 2015, 27(5): 4725–4736. ...
We further explored the mechanisms of PRC2 gene up-regulation in metastatic tumor cells and found up-regulation ofE2Fgenes,MYCtargets and down-regulation of tumor suppressor gene E-cadherin targets in lymph node metastasis through GSEA analyses. Using IHC, the expression of potential EZH2 target, ...
(Fig. 4).EPHB4was reported to be a tumor suppressor gene silenced by DNA hypermethylation in acute lymphoblastic leukemia and transduction ofEPHB4resulted in down-regulation of phosphorylated Akt43.WNT7Awas reported to be decreased in non-small cell lung cancer (NSCLC) and its transfection into ...
展开 关键词: Arabidopsis Angiosperms Zea mays Seeds DNA (Cytosine-5-)-Methyltransferase Repressor Proteins MADS Domain Proteins Gene Expression Regulation, Developmental Gene Expression Regulation, Plant Genomic Imprinting DOI: 10.1371/journal.pgen.1003862 被引量: 86 年份...