Whereas PPARa operates in the catabolism of fatty acids in the liver, PPAR gamma influences the storage of fatty acids in the adipose tissue and plays a role in adipocyte differentiation. PPARg binds to DNA as a heterodimer with retinoid X receptor (RXR), activating expression of target genes ...
(c,d) CC reduced mRNA expression of PPARγ target genes in liver tissue (c) and white adipose tissue (d) (n = 6). CC is presented as CC-2 (100 mg/kg) Data are expressed as the mean ± SEM. *p < 0.05, **p < 0.01, CC vs HF mice. Full size image To...
weeks, a single injection of adenoviral vector-based short hairpin interfering RNA against PPARγ2 in HF butter-fed mice reduced PPARγ protein and mRNA of its target genes (CD36 and ADRP) by 43%, 43%, and 39%, respectively, with a reduction in liver TG concentration by 38% in 5 ...
The mechanisms involved in such differences remain largely unknown. Several studies have identified the major target genes of PPARα agonists in rodent liver while no comprehensive analysis has been performed on gene expression changes induced by PPARγ and dual PPARα/γ agonists. Here, we ...
To identify PPARγ target genes, microarray analysis was performed using GeneChip technology on EVCT primary cultures obtained from first-trimester human placentas. Gene expression was compared in EVCTs treated with the PPARγ agonist rosiglitazone versus control. A total of 139 differentially regulated...
Wuhan Integrated TCM & Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Aim: To study the probable mechanisms of the anti-glomerulosclerosis effects induced by peroxisome proliferator-activated receptor gamma (PPARγ) agonists in rat in...
Subunit : Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of tar...
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature. 2007;447(7148):1116–20. Article CAS PubMed PubMed Central Google Scholar Download references Acknowledgements We acknowledge the National Key R&D Program of China, the technology Major Project in ...
The pre- dicted PPARg-binding sites on the promoter of target genes were validated by ChIP-PCR (specific primers listed in Table 1). & 2012 Cancer Research UK British Journal of Cancer (2012) 106(9), 1486 – 1494 1488 Table 1 PPARgamma inhibits liver cancer metastasis B Shen et al ...
Furthermore, the HIF1α- and c-Myc- target genes GAPDH, PGK1, ENO1, were not regulated in an Akt2- dependent manner in livers (Fig. 1). These observations would be consistent with extra mechanisms downstream of Akt2 control- ling PKM2 and HK2 expression. We noticed that fat storing ...