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Subunit : Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of tar...
Integrating PPARα and PPARγ genomic occupancy with cold-responsive BAT transcriptomes identifies a subset of 16 genes with potential relevance to BAT function. Among these, we focused on the lysosomal protease cathepsin Z (CTSZ) and showed it is necessary for mitochondrial respiration in both ...
In summary, our findings show that the transcription factor PPARγ phase separates with its heterodimer partner RXRα to concentrate the transcription machinery specifically at PPREs to efficiently regulate the transcription of PPARγ-targeted genes. This study provides an alternative strategy for the mo...
重组人过氧化物酶增殖物激活受体γ (LBD) (His-tagged)又称PPAR-gamma, Peroxisome Proliferator-activated Receptor γ Ligand Binding Domain, PPAR-gamma (LBD), NR1C3, PPARG (LBD).其对应NCBI基因号为5468.来源宿主 提供的【PPARG】重组人过氧化物酶增殖物激活受体γ (LBD) (His-tagged)蛋白产品来源为大肠...
By modifying chromatin structure early in development, obesogens have the opportunity to influence the promoter activity of PPARγ, or the ability of PPARγ to bind to its target genes, ultimately biasing the progenitor pool towards the fat lineage. Obesogens that act by directly or indirectly ...
4b). Among the cocaine-induced PPARγ target genes, none were common oscillators in both genotypes. The significant fraction of de novo cycling PPARγ target genes induced by the first exposure to cocaine in WT mice, prompted us to further explore the involvement of this nuclear factor. Phase...
Peroxisome proliferators activated receptor gamma (PPARγ), like estrogen receptor alpha (ERα), is a nuclear receptor that is highly expressed in breast cancer. While ERα ligands activate proliferation, PPARγ ligands have been shown to induce differentiation in breast cancer cells. Furthermore, ...
背景资料 ng to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. PPARA(peroxisome prolif...
In an attempt to identify new PPARalpha and PPARgamma target genes in macroph... G Chinetti,C Zawadski,JC Fruchart,... - 《Biochemical & Biophysical Research Communications》 被引量: 1227发表: 2004年 Pharmacological characterization of a human-specific peroxisome proliferater-activated receptor α...