Cooper EC. Potassium Channels (including KCNQ) and Epilepsy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado- Escueta AV, editors. Source Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th ed. Bethesda, MD: National Center for Biotechnology Information (US); 2012 [PMID:...
Cooper EC. Potassium Channels (including KCNQ) and Epilepsy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado- Escueta AV, editors. Source Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th ed. Bethesda, MD: National Center for Biotechnology Information (US); 2012 [PMID:...
ERG channels, a subgroup of the voltage-gated potassium channel family, have been widely expressed both in the central nervous system (CNS) and the heart. Biophysical Properties of ERG Channels in Octopus Neurons of Ventral Cochlear Nucleus The identification of potassium channel modulators is of co...
To explore the mechanisms underlying the behavioral and seizure and juvenile death phenotypes in Ank2-cKO mice, we characterized neuronal excitability and synaptic transmission in the somatosensory cortex (SSC), which is a brain region that has been frequently implicated in ASD19,20 and epilepsy21....
Structure and mechanism of the K+/H+ exchanger KefC Intracellular potassium (K+) homeostasis is achieved by activity of both ion channels and transporters. Here, the authors report structures of E. coli glutathione (GSH)-gated K+ efflux transporter KefC with bound K+ and conclude that the...
Benign familial neonatal convulsions (BFNC) is an autosomal dominant epilepsy of infancy, with loci mapped to human chromosomes 20q13.3 and 8q24. By positional cloning, a potassium channel gene (KCNQ2) located on 20q13.3 was isolated and found to be expressed in brain. Expression of KCNQ2 ...
Disorders of membrane channels or channelopathies (2) potassium channelopathies: benign infantile epilepsy, episodic ataxia type 1; (3) calcium channelopathies: episodic ataxia type 2, spinocerebellar ... GG Celesia - 《Clinical Neurophysiology》 被引量: 119发表: 2001年 Neurological potassium channe...
K-ATP channels have been implicated in diverse metabolic processes as well as pathological conditions such as diabetes, ischemia and hypoxia, and epilepsy. A PCR-based cloning strategy has identified many novel potassium channel clones; expression of one clone isolated from rat heart resulted in ...
Potassium channels significantly influence neural activity by regulating the duration of action potentials and neurotransmitter release [5,6,7]. Previous studies highlight that potassium channels are closely linked to the occurrence and progression of various diseases, such as arrhythmias [8], epilepsy ...
neural KCNQ channels are drug targets for the treatments of epilepsy and a variety of neurological disorders, including chronic and neuropathic pain, deafness, and mental illness. This review will update readers on the roles of KCNQ channels in the sensory system and neural circuits as well as di...