Ion channels and epilepsy in man and mouse. Curr. Opin. Genet. Dev. 10:286-291.Steinlein O K,Noebels J L.Ion channels and epilepsy in man and mouse[J].Curr Opin Genet Dev,2000,10(3):286-291.Ion channels and epilepsy in man and mouse. Steinlein OK,Noebels JL. Curr Opin ...
Review Ion channels and epilepsy 来自 Semantic Scholar 喜欢 0 阅读量: 33 作者: Graves T.D 摘要: During the past 10 years, there has been an upsurge in the discovery of epilepsy-causing mutations in genes encoding ion channel proteins. Good genotype-phenotype correlation is possible in BFNC,...
Ion channels in retinal pigment epithelial (RPE) cells are crucial for retinal health and vision functions. Defects in such channels are intricately associated with the development of various retinopathies that cause blindness. Human pluripotent stem cells (hPSC)-derived RPE cells, including those fro...
Smaller regulatory subunits (α2, β, Δ, γ) may influence the gating behavior of the channel and modify its expression level in the plasma membrane. The pores of most ion channels have a selectivity filter, which permits the channel to conduct only a single type of ion. However, ligand-...
Ion Channels and Epilepsy The role of voltage-gated and ligand-gated ion channels in epileptogenesis of both genetic and acquired epilepsies, and as targets in the development of ne... J.,Armijo,M.,... - 《Current Pharmaceutical Design》 被引量: 216发表: 2005年 Trimeric architecture of ho...
The unique importance of KCNQ2 / 3 channels in maintaining normal levels of excitability is proved by the findings that a genetic or experience dependent reduction of channel activity is associated with neuronal hyper excitability related brain disorders, such as epilepsy and tinnitus....
Extrasynaptic GABA and glutamate receptors in epilepsy. Epilepsy is a neurological disorder in which normal brain function is disrupted as a consequence of intensive and synchronous burst activity from neuron as... German Sierra-Paredes, German Sierra-Marcuno - CNS & Neurological Disorders - Drug Ta...
Fraction of channels that inactivate through slow inactivation g: Conductance GEFS+: Genetic (generalized) epilepsy with febrile seizures plus GPD1L: Glycerol-3-phosphate dehydrogenase 1-like protein I: Current ICD: Intracellular domain Ig: Immunoglobulin ...
Ion channels are involved in a variety of fundamental physiological processes, and their malfunction causes numerous human diseases. Therefore, ion channels represent a class of attractive drug targets and a class of important off-targets for in vitro ph
Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential Mechanism 来自 掌桥科研 喜欢 0 阅读量: 2 作者: Y Liu,D Xia,Zhong, LianmeiChen, LingZhang, LinmingAi, MingdaMei, RongPang, Ruijing 摘要: Epilepsy, characterized by recurrent seizures and abnormal brain discharges, is the...