Seizures, Epilepsy, and SUDEP: A Change of Heart? Prolongation of Action Potential Duration and QT Interval During Epilepsy Linked to Increased Contribution of Neuronal Sodium Channels to Cardiac Late Na+ Current: Potential Mechanism for Sudden Death in Epilepsy... BN Smith - 《Epilepsy Currents》 ...
Rock DM, McLean MJ, Macdonald RL, Catterall WA, Taylor CP (1991) Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-alpha-benzoate binding in vitro. Epilepsy Res 8: 197–203. CAS Pub...
Action potentials were then evoked under current-clamp mode by injecting current pulses (− 50 to + 300 pA, in 10 or 50 pA increments for 1000 ms) from an initial holding potential of − 70 mV. The threshold for AP generation was measured as the beginning of the upward rise ...
A disease of the brain produced by the uniform firing of groups of neurons such that the normal generation and processing of directed action potentials in the affected area is disrupted and the...Springer Berlin Heidelbergdoi:10.1007/978-3-642-16483-5_1951...
Anticonvulsants, neuronalpotassiumchannel opener.Stabilizes neuronal KCNQ (Kv7) channels in the open position, increasing the stabilizing membrane current and preventing bursts of action potentials during the sustained depolarizations associated with seizures. ...
Application of NPY ameliorates epileptiform activities in vitro with a reduced number of paroxysmal depolarizing shifts and action potentials in the resected human hippocampus. This result advocated for the NPY-Y2 therapy as a potent candidate for future clinical application in drug-resistant TLE ...
This influx of ions has a direct impact on excitatory events, exerting a substantial influence on neural synchronization and potentially giving rise to action potentials within neurons. An essential biological mechanism that intensifies epileptic seizures involves the protein IL-1β. Furthermore, IL-1...
Application of NPY reduced overall number of paroxysmal depolarising shifts and action potentials. This effect was mediated by Y2 receptors, since application of selective Y2-receptor antagonist blocked the effect of NPY. This proof-of-concept finding is an important translational milestone for ...
To record evoked action potentials (eAPs), glass pipette electrodes were filled with an internal solution of the following composition (in mmol/L): 60 K2SO4, 40 HEPES, 4 MgCl2·6H2O, 60 N-methyl-d-glutamine, 0.5 BAPTA, 12 phosphocreatine, 2 Na2ATP, and 0.2 Na3GTP. Neuronal eAPs at res...
In addition, dendrites of human pyramidal cells show complex calcium-mediated action potentials266, a high threshold for NMDA spikes267 and faster backpropagation of action potentials as well as forward propagation of excitatory postsynaptic potentials268. The uniqueness or generality of these recently ...