called Potassium-Competitive Acid Blockers (P-CABs) [17,18,19], which share the same target as the PPIs (i.e. the gastric proton pump) but inhibit it through a completely different molecular mechanism. They block the K+exchange channel of the proton pump, resulting in a very fast, compe...
However, a major advance has been the development of the potassium-competitive acid blockers (P-CABs), which block the K,H-ATPase potassium channel, are food independent, are reversible, have a rapid onset of action, and maintain a prolonged and consistent elevation of intragastric pH. ...
Some sodium channel blockers inhibit the late component of the current more potently (i.e., at lower concentrations) than they do the fast (peak) sodium current (Ono et al., 2000; Nagatomo et al., 2002). Ideally, the effect of drugs on peak and sustained sodium current should be ...
In contrast, different blockers such as dequalinium, amiodarone [47], and others [45] inhibit the proliferation of MCF-7 cells. K+ channel blockers also potentiate the growth-inhibitory effects of tamoxifen in human breast, prostate, and colon cancer cell lines [47]. In addition, the ...
Purpose of the review The introduction of H2-receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) into clinical practice has been a real breakthrough in the treatment of acid-related diseases. PPIs are now the standard of care for the treatment of gastroesophageal reflux disease (GERD...
In a special embodiment, the compounds of the invention are SK channel blockers, such as SK3 channel blockers. Based on the activity observed in the patch clamp experiments, the compound of the invention is considered useful for the treatment, prevention or alleviation of a disease or a ...
The problem is now clearly focused, and further work amplifying the signature channel properties of the apical membrane surely will clarify these questions for the parietal cell. Show moreView chapterExplore book Related terms: Adenosine Triphosphate Aldosterone Glutamic Acid Ischemia Cell Membrane Calcium...
Therapeutic Effect:Increases gastric pH, reduces gastricacid production. Uses Treatment ofgastroesophageal reflux disease(GERD), severeerosive esophagitis, poorly responsive systemic GERD, pathologic hypersecretory conditions (Zollinger-Ellison syndrome,systemic mastocytosis, multiple endocrine adenomas), withclarit...