called Potassium-Competitive Acid Blockers (P-CABs) [17,18,19], which share the same target as the PPIs (i.e. the gastric proton pump) but inhibit it through a completely different molecular mechanism. They block the K+exchange channel of the proton pump, resulting in a very fast, compe...
Potassium-com- petitive acid blockers: advanced therapeutic option for acid-related diseases. Pharmacol Ther 2016;168:12-22.Inatomi N, Matsukawa J, Sakurai Y, Otake K. Potassium-competitive acid blockers: Advanced therapeutic option for acid-related diseases. Pharmacol Ther 2016;168:12-22....
potassium competitive acid blockersclinical trialspatient managementtherapyGastroesophageal reflux disease (GERD) and Helicobacter pylori (H. pylori) infection are different disease states that are united by the core role of acid suppression in their management. In GERD, proton pump inhibitors (PPIs) ...
PYRIMIDINE CYANOGUANIDINES AS K-CHANNEL BLOCKERS Cyanoguanidine compounds of formula (I) and its pharmaceutically acceptable acid addition salts wherein X is CH or N; R1 is hydrogen or methyl; R2 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C5 cycloalkyl, hydroxy-C1-C5 alkyl, metho...
In this section, we will review the role and efficacy of gastric acid suppressants, including PPIs and potassium-competitive acid blockers (P-CABs), in the treatment of H. pylori infection.Springer, SingaporePark, Chan HyukHanyang University Guri Hospital, Hanyang University College of Medicine...
Hence, the present study aimed to elucidate the role of K+ channels during nervous necrosis virus (NNV) infections in the sevenband grouper (Hyporthodus septumfasciatus). Real-time PCR with the standardized potassium genes revealed the downregulation of potassium two pore domain channel subfamily ...
The K+ channel openers cromakalim and pinacidil induced a concentration-dependent reduction in atrial contraction force with EC50 values of 25 ± 2 and 37 ± 2 μmol/l, respectively. This depressant effect was antagonised by 50 μmol/l tacrine which displace...
salt- a compound formed by replacing hydrogen in an acid by a metal (or a radical that acts like a metal) Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc. Want to thank TFD for its existence?Tell a friend about us, add a link to this...
polypeptide K+channel blockers from scorpion venom Kv: voltage-gated K+channels RP-HPLC: reversed-phase high-performance liquid chromatography SKCa: small-conductance calcium-activated K+channels TEA: tetraethylammonium TM: transmembrane (segment). ...
On the other hand, the potassium channel may regulate multidrug-related protein resistance to the tumor. Targeting potassium channel drugs overcomes tumor resistance, enhancing the accumulation of drugs in the tumor. Potassium channel blockers, including glibenclamide and tetraethylammonium, suppress t...