Charybdotoxin can increase quantal content, but this is more likely to result from block of voltage-dependent K+ channels than Ca(2+)-activated channels: the increase in transmitter release occurred in conditions in which little IKCa would be present; higher concentration of charybdotoxin and ...
Potassium bromide was used to titrate the aliquots. The triturated slurry was then compressed to form thin discs. An FT-IR spectrophotometer (IR-470, Shimadzu, Kyoto, Japan) was used to collect IR spectra in the 400–4000 cm−1 range. Differential Scanning Calorimetry (DS...
and potassium carbonate (1.1 equiv.) in acetone (5 mL/mmol of 1) was treated with 1.2 equiv. of an alkyl/arylsulfonyl chloride. The mixture was stirred under reflux for 3 h and then cooled to room temperature. The salt was filtered off on a sintered funnel and washed with cold acetone...
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In different cell types, a ROS-mediated interaction (i.e. cross-talk signaling) between the plasma membrane Nox2 and mitochondria was observed, and ROS derived from the Nox2-released superoxide leads to opening of mitochondrial ATP-sensitive potassium channels (mitoKATP), which enhances generation...
HILLE, B.: Quaternary ammonium ions that block the potassium channel of nerves. Biophys. Soc. Abst. WC3, (1967). KORENBROT, J.I., R. A. CONE: Dark ionic flux and the effects of light in isolated rod outer segments. J. Gen. Physiol. 60, 20–45 (1972).PubMedView Article TOMITA,...
SCORPION PEPTIDES THAT BLOCK HUMAN T-LYMPHOCYTE POTASSIUM CHANNELS AND METHOD OF USE THEREOF Potassium channels hKv1.3 are known to be implicated in immunological diseases and graft rejections. Disclosed are peptides capable of blocking with high a... D Lourival,GEORGINA,P Saida,... 被引量: ...
Her research focuses on ATP-sensitive potassium channels and their role in insulin secretion in both health and disease. She is interested in how channel function relates to structure, and in particular how nucleotides regulate channel activity. The ultimate goal is to elucidate how a rise in the...
The apoptosome formation is also influenced by intracellular nucleotides, potassium and calcium concentration. As regards intracellular nucleotides, it has been demonstrated that they have an inhibitory role on apotosome in normal conditions (49,50). In particular, they bind to the lysine residues of...
called ion channels, involved in passing electrical signals between neurons and other cells. They studied a fly gene necessary to block stress-induced seizures, called sei, which functions throughout the nervous system and in the heart. They found that sei primarily protects against heat-induced se...