Post-transcriptional modifications of RNA play an important role in a wide range of biological processes. In ribosomal RNA (rRNA), methylation of nucleotide bases is the predominant modification. In recent years, methylation of adenosine 2503 (A2503) in bacterial 23S rRNA has attracted significant ...
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Post-transcriptional modifications of the tRNA anticodon stem and loop (ASL) affect the ability of tRNA to bind synonymous codons 来自 repository.lib.ncsu.edu 喜欢 0 阅读量: 49 作者: EM Gustilo 摘要: The Genetic Code is arranged into sixteen codon boxes, where the four codons in each box ...
Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent EvolutionThe high conservation of nucleotides of the T-loop, including their chemical identity, are hallmarks of tRNAs from organisms belonging to the three Domains of Life. These ...
Post-transcriptional modifications by the alternative splicing of mRNA transcripts are critical regulatory mechanisms of mammalian gene expression. In the heart, there is an expanding interest in elucidating the role of alternative splicing in transcriptome regulation. Substantial efforts were directed toward...
Posttranslational modifications of the master transcriptional regulator NPR1 enable dynamic but tight control of plant immune responses. Cell Host Microbe, 18(2): 169- 182Saleh, A., Withers, J., Mohan, R., Marques, J., Gu, Y., Yan, S., et al. (2015). Posttranslational modifications ...
The function of regulatory proteins – such as protein kinases39, transcription40and chromatin remodeling factors41,42– is fine-tuned through post-translational modifications (PTMs). Increasing evidence indicates that the activity of RBPs can also be regulated by PTMs24,43. We collected the modifi...
translation and decay in processes such as cell differentiation, embryonic development and stress responses. Other mRNA modifications, includingN1-methyladenosine (m1A), 5-methylcytosine (m5C) and pseudouridine, together with m6A form the epitranscriptome and collectively code a new layer of information ...
, 2018. RNA Framework: an all-in-one toolkit for the analysis of RNA structures and post-transcriptional modifications. Nucleic Acids Research [PMID: 29893890] License This program is free software, and can be redistribute and/or modified under the terms of the GNU General Public License as ...
Splice Seeking: Quantifying Post-transcriptional Modifications with Proteomics Following characterization, estimates show that between 92% and 94% of all human genes are capable of alternative splicing, a post-transcriptional modification that rearranges how the genetic code is read and turned i...