Part of the maturation process of small RNAs are post-transcriptional modifications either on the ribose or base moiety of the nucleotide. Additionally, deletion and/or addition of nucleotides by RNA-specific ribonucleotidyl transferases are also plausible (RNA 13:1834–1849, 2007). In this ...
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat Cell Biol. 2007;9:428–35. Article CAS PubMed Google Scholar Wang Z, Prelich G. Quality control of a transcriptional regulator by SUMO-targeted degradation. Mol Cell Biol. 2009;29:1694–706. Article PubMed ...
Post-translational modifications are modifications that occur on a protein, catalysed by enzymes, after its translation by ribosomes is complete. Post-translational modification generally refers to the addition of a functional group covalently to a protein as in phosphorylation and neddylation, but also...
this chapterwillfocusonthemodificationsthataremostfrequentlyencountered whenexaminingregulationofgeneexpressionthroughtranscriptionfactor (TF)analysis.Thesemodificationsoccurinthemajorityofproteinsinvolvedin transcriptionalregulation,includingtranscriptionfactors,coactivators,repres- sors,generaltranscriptionfactors,histones,andRNA...
Acetylated proteins can also be modulated by the cross-talk with other posttranslational modifications, including phosphorylation, ubiquitination, and methylation [58]. Therefore, acetylation may contribute to cell biology beyond transcriptional regulation [59]. 3.1.3. Protein Glycosylation Protein ...
The Genetic Code is arranged into sixteen codon boxes, where the four codons in each box are similar in their first two letters but differ at the third position (the wobble position). In the universal Genetic Code, each amino acid, except for Tryptophan and Methionine that have one codon ea...
During cell differentiation, pRb was acetylated at K873/K874 by p300-Associated Factor (P/CAF) and P/CAF could cooperate with p300 to enhance the pRb acetylation, which exerted no impact on pRb-mediated acute cell cycle arrest or repressive function of pRb on E2F transcriptional activities [...
Post-translational modifications (PTMs) include a collection of add-ons that provide variability to a defined set of proteins that all cells use to enable most biological processes, adapting the functionality of those proteins by varying their interactive capability, resistance to degradation, etc. In...
(1) changing the chromatin structure into activated or repressed transcriptional state (2) acting as a docking site for transcriptional regulators Chromatin Remodeling – mechanisms for transcription-associated structural changes in chromatin Acetylation in Histone H3 Globular Domain Regulates Gene Expression ...
Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function 翻译后修饰在调节c-Myc蛋白水解、转录活性和生物学功能中的作用 相关领域 磷酸化 癌变 蛋白质水解 生物 细胞生物学 泛素 转录调控 功能(生物学) 细胞周期 细胞凋亡 转录因子 基因 遗传学 ...