(2012) "Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain." Nat Med. [Epub ahead of print] :Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, ...
Post-ischemic inflammation is a dynamic process involving a complicated set of interactions among various inflammatory cells and molecules. The resident inflammatory brain cells, microglia, are especially activated in response to ischemic insults, many of which are regulated by nuclear transcription factor...
CONCLUSIONS: Our data demonstrate that systemically applied Lin(-)-HSCs reduce cerebral postischemic inflammation, attenuate peripheral immune activation and mediate neuroprotection after ischemic stroke. 展开 关键词: cell therapy cerebral ischemia hematopoietic stem cells neuroprotection postischemic inflammation...
Together, these results indicate DEOPA has multi-modal protective effects against ischemic brain damage targeting numerous cell types in the brain and also against other inflammation-related diseases. Ethyl pyruvate (EP) is a simple aliphatic ester of pyruvic acid and has been reported to mitigate ...
Infiltrating immune cells sustain the post-ischemic inflammation for several days; after this period, however, these cells take on a repairing function, phagocytosing inflammatory mediators and cellular debris. This time-specific polarization of immune cells in the ischemic brain is a potential novel ...
These findings indicate that both acute and 24h BAY 60 treatment prior to brain I/R limits postischemic inflammation, and may have therapeutic value for suppressing stroke-mediated damage. Supported by grants from the NIH (AA-014945 and HL-095486). BAY 60-2770 was a gift from Bayer Schering...
WH Trescher,S Ishiwa,MV Johnston - 《Brain Dev》 被引量: 329发表: 1997年 Influence of hypothermia on post-ischemic inflammation: Role of nuclear factor kappa B (NFκB) Mild hypothermia is one of the most robust neuroprotectant studied in the laboratory to date. The reasons for this protec...
关键词: MCAO fluoxetine inflammation neuroprotection DOI: 10.1002/jnr.21899 被引量: 93 年份: 2009 收藏 引用 批量引用 报错 分享 全部来源 求助全文 ProQuest ResearchGate onAcademic 相似文献 参考文献 引证文献Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory ...
Kapadia,R Yi,JH Vemuganti - 《Frontiers in Bioscience》 被引量: 569发表: 2008年 Role of transcription factors in mediating post-ischemic cerebral inflammation and brain damage Yi JH, Park SW, Kapadia R, Vemuganti R. Role of transcription factors in mediating post-ischemic cerebral inflammation...
Mice were sacrificed from 1 to 28days later to phenotype and map subsets of infiltrating monocytes/macrophages (Mo/MΦ) in the brain over time. Flow cytometry analysis 3 and 14days after MCAo in CCR2/mice, which exhibit deficient monocyte recruitment after inflammation, and NR4A1/BM chimeric ...