Post-ischemic inflammation is an essential step in the progression of brain ischemia-reperfusion injury. In this review, we focus on the post-ischemic inflammation triggered by infiltrating immune cells, macrophages, and T lymphocytes. Brain ischemia is a sterile organ, but injury-induced inflammation...
Post-ischemic inflammation is an essential step in the progression of brain ischemia-reperfusion injury. However, the mechanism that activates infiltrating macrophages in the ischemic brain remains to be clarified. Here we demonstrate that peroxiredoxin (Prx) family proteins released extracellularly from ...
In ischemic stroke, only a portion of the brain is at risk, and the ischemia is only complete in the center of the vulnerable area. This central area of dense ischemia is surrounded by a penumbral zone in which blood flow is diminished but not completely lost. As opposed to CA with ...
Effects of Lin(-)-HSCs injection on infarct size, apoptotic cell death, postischemic inflammation and cytokine gene transcription were analyzed. RESULTS: Green fluorescent protein (GFP)-marked Lin(-)-HSCs were detected at 24 hours after injection in the spleen and later in ischemic brain ...
Together, these results indicate DEOPA has multi-modal protective effects against ischemic brain damage targeting numerous cell types in the brain and also against other inflammation-related diseases. Ethyl pyruvate (EP) is a simple aliphatic ester of pyruvic acid and has been reported to mitigate ...
Accumulated extracellular HMGB1 mediates acute and delayed damaging processes, especially aggravating inflammation in the postischemic brain16. HMGB1 is known to interact with various molecules, such as lipopolysaccharides (LPS), interleukin-1β (IL-1β), single-stranded DNA, Pam3CSK4, CpG ...
EA treatment also decreased the number of autophagosomes in these rats. Conclusions EA effectively mitigates post-stroke cognitive impairment by reducing apoptosis, inflammation, and autophagy through the regulation of the mTOR/NLRP3-mediated autophagy-inflammatory pathway, offering valuable therapeutic ...
These results demonstrate that curative treatment of fluoxetine affords strong protection against delayed cerebral ischemic injury, and that these neuroprotective effects might be associated with its anti-inflammatory effects. 展开 关键词: MCAO fluoxetine inflammation neuroprotection ...
Together, these results indicate DEOPA has multi-modal protective effects against ischemic brain damage targeting numerous cell types in the brain and also against other inflammation-related diseases. Similar content being viewed by others Allicin promotes functional recovery in ischemic stroke via ...
encephalitis- inflammation of the brain usually caused by a virus; symptoms include headache and neck pain and drowsiness and nausea and fever (`phrenitis' is no longer in scientific use) cephalitis,phrenitis inflammation,redness,rubor- a response of body tissues to injury or irritation; character...