Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human HealthRNA modificationEpitranscriptomicstRNA modification disease biomarkersEmerging RNA modification technologyEpitranscriptomics is the study of global modification patterns to both coding and noncoding RNA. Understanding the ...
Posttranscriptional modification in tRNA is known to play a multiplicity of functional roles, including maintenance of tertiary structure and cellular adaptation to environmental factors such as temperature. Nucleoside modification has been studied in unfractionated tRNA from three psychrophilic bacteria (ANT-...
There are fewer tRNA species than codons; therefore, a tRNA species can recognize more than one codon. This flexibility in recognition resides in the third position of the codon:anticodon pairing, the wobble position. 展开 关键词: Biochemistry Post-transcriptional modifications of the tRNA anticodon...
ARTICLE Received 18 Jan 2013 | Accepted 7 May 2013 | Published 10 Jun 2013 DOI: 10.1038/ncomms2984 Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible Pulkit Gupta1, Shanmugapriya Sothiselvam1, Nora Va´zquez-Laslop1 & Alexander S...
modificationrrnatrnarna间隔区genes RNAPosttranscriptionalProcession转录后加工ClassesofRNA•Pre-RNA,前体RNA:Theprimarytranscripthasthesameorganizationasthegene•hnRNA,heterogeneousnuclearRNA,核内不均一RNA:EucaryoticRNAPolIItranscribesavarietyofdifferentgenes•snRNA,smallnuclearRNA,核内小RNA:isanyoneofmanysmallRN...
To fulfil their functions within cells, tRNAs undergo a tightly controlled biogenesis process leading to the formation of mature tRNAs. In particular, the introduction of post-transcriptional modifications in tRNAs is controlled and influenced by multiple factors. In turn, tRNA biological functions are ...
Novel mechanism of post-transcriptional modification of tRNA: insertion of base of Q precursor into tRNA by tRNA transglycosidase ... Base rate of post-concussion symptoms among normal people and its neuropsychological correlates. An examination of the base rates of post-concussion symptoms: the infl...
In tRNA, dihydrouridine is a conserved modified base generated by the post-transcriptional reduction of uridine. Formation of dihydrouridine 20, located in the D-loop, is catalyzed by dihydrouridine synthase 2 (Dus2). Human Dus2 (HsDus2) expression is upregulated in lung cancers, offering a...
Characterization of a two-component system transcriptional regulator LtdR that impacts group B streptococcal colonization and disease. Infect. Immun. https://doi.org/10.1128/IAI.00822-17 (2018). Namugenyi, S. B., Aagesen, A. M., Elliott, S. R. & Tischler, A. D. Mycobacterium tuberculosis...
for tRNA thiolation. Analysis of protein-protein interaction shows binding of CTU2 to ROL5, the CTU1 homolog of Arabidopsis. The analysis of actu2knock-out mutant reveals an effect on root development, suggesting that the modification of tRNAs is particularly important for root developmental ...