Microbial antibiotic resistance remains a serious public health problem worldwide. Conventional culture-based techniques are time-taking procedures; therefore, there is need for new approaches for detecting bacterial resistance. The aim of this study was to assess antibiotic resistance ofEscherichia coliby...
Infection therapy: the problem of drug resistance – and possible solutions 来自 学术范 喜欢 0 阅读量: 41 作者: H Brüssow 摘要: The rising antibiotic resistance in major bacterial pathogens together with the breakdown of the antibiotic discovery platform creates a critical situation for infection ...
The mutations that confer antibiotic resistance lead, in most cases, to a decrease in fitness. Here, Andersson and Hughes describe the various ways in which bacteria can minimize the fitness cost and how this may be exploited to reverse antibiotic resist
Most antibiotic resistance mechanisms are associated with a fitness cost that is typically observed as a reduced bacterial growth rate. The magnitude of this cost is the main biological parameter that influences the rate of development of resistance, the stability of the resistance and the rate at ...
To analyze the possible harm of using an antibiotic-resistant gene as a selectable marker in plasmids for gene transfer in the production of genetically modified (GM) food, we can evaluate each of the given statements step by step. 1. Understanding the Use of Antibiotic Resistance Genes: - An...
Furthermore, swelling assays with antibiotic solutions made it possible to compute the role of this protein complex in antibiotic resistance. 展开 关键词: Bacteroides fragilis, porin, polymeric forms, antibiotic resistance DOI: 10.1006/anae.2001.0385 被引量: 10 ...
“Normally, during orgasm, the muscles at the base of the bladder tighten up to prevent this from happening, and semen follows the path of least resistance and travels through the urethra and out of the body. However, if the muscles at the base of the bladder are weakened or not ...
Numbers of small molecular inhibitors with different active sites and time phases are commonly used in the research of F1F0-ATP synthase functions20. Oligomycin, an antibiotic produced by Streptomyces diastatochromogens, can bind to the F0 sector, and inhibit the InATP synthesis and hydrolysis21;...
Cox G, Wright GD. Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions. Int J Med Microbiol. 2013;303:287–92. CASPubMedGoogle Scholar Olivares J, Bernardini A, Garcia-Leon G, Corona F, Sanchez MB, Martinez JL. The intrinsic resistome of bacterial pathogens. Front Mi...
The default covalent-docking technique refines the docking solutions obtained during the placement step using MOE's rigid receptor scheme and then rescored using the force field-based GBVI/WSA scoring function to determine the free binding energy associated with the given pose [74]. Despite the ...