Spread of antibiotic resistance to different environmental niches and development of superbugs have further complicated the effective control strategies. International, national and local approaches have been advised for control and prevention of antimicrobial resistance. Rational use of antimicrobials, ...
In this context, this review presents a panel of promising and potential strategies to combat antibiotic resistance/resistant bacteria. Different types of direct-acting and indirect resistance breakers, such as efflux pump inhibitors, antibiotic adjuvants, and oxidative treatments are discussed. In ...
She noted the challenges in antimicrobial research and development (R&D) investment and advocated for innovative approaches, including biologics and advanced diagnostics, to combat antimicrobial resistance. “Real-world evidence data is great because one of the things that it allows us to do is reall...
Moreover, resistant bacteria can grow under antibiotic pressure, their resistant phenotype is inheritable, and a significant increase in the minimal inhibitory concentration (MIC) of antibiotics is required to effectively kill them [14]. However, resistance phenotypes are not always due ...
REVIEWS Anti-virulence strategies to combat bacteria-mediated disease David A. Rasko* and Vanessa Sperandio‡ Abstract | Antibiotic resistance is one of the greatest challenges of the twenty-first century. However, the increasing understanding of bacterial pathogenesis and intercellular communication has...
Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance. Expert Opin. Drug Discov. 5, 883–902 (2010). Article CAS PubMed Google Scholar Hagihara, M., Crandon, J. L. & Nicolau, D. P. The efficacy and safety of antibiotic combination therapy for infections ...
Many common nosocomial pathogens have growing rates of antibiotic resistance, exacerbating the situation and emphasizing the need for preventative alternatives to antibiotic treatment, such as immunological strategies based on vaccine development or therapeutic antibodies, which may significantly enhance their ...
Therefore, to address the problem of antibiotic resistance, effective strategies are required. This review will summarize and discuss various strategies to minimize antibiotic resistance. 2. Appropriate Antibiotic Prescribing Since the resistance to the first commercial antimicrobial agent (penicillin) was ...
Antibiotic resistance is of much prevalence and is one of the alarming realities for the rise in morbidity and mortality. Antibiotics; once regarded as wonder drugs have lost its credit of combating bacteria due to the rapid rise in variety of nosocomial pathogens. The underlying cause for the ...
Antibiotic resistance is projected as one of the greatest threats to human health in the future and hence alternatives are being explored to combat resistance. Antimicrobial peptides (AMPs) have shown great promise, because use of AMPs leads bacteria to develop no or low resistance. In this revie...