The gut microbiome has an important role in human health. In addition to its structural and metabolic functions, it protects the host against colonization by many external pathogens.8It is also a known reservoir for a wide variety of antibiotic resistance genes, from the resident “...
With only a few antibiotics in development and a long drug development process (often 10-15 years), there is concern that what is being done to combat antibiotic resistance may be 'too little, too late'. "If bacteria continue developing resistance to multiple antibiotics at the present rate, ...
One possible therapeutic target is the BfmRS two‐protein signaling system, which activates many genes that determine antibiotic resistance and virulence in A. baumannii. The transcription factor, BfmR, is key to this gene regulation pathway. How the activity of BfmR is ...
are resistant to all our current drugs.So, what can we do about this?We need to control the use of existing antibiotics, create new ones,combat resistance to new and existing drugs,and find new ways to fight bacterial infections.The largest consumer of antibiotics is agriculture,which uses ...
What is Antimicrobial Resistance? Antibiotic resistance. Multi-drug resistance. Drug resistant infections. Multi-resistant organisms. These are all terms that encapsulate a single phenomenon, one that has been labeled by the World Health Organization as one of the biggest threats to public health this...
Queensland researchers have discovered that a mutation allows someE. colibacteria to cause severe disease in people while other bacteria are harmless, a finding that could help to combat antibiotic resistance. Professor Mark Schembri and Dr. Nhu Nguyen from The University of Queensland’s Institute ...
In the meantime, individual GPs can do their part to prescribe antibiotics better, and patients can join the national effort to combatantibiotic resistanceby asking their GP, "what would happen if I don't take an antibiotic?" Provided byThe Conversation ...
Propose a plan for awareness-raising on iatrogenesis prevention in drug treatments through pharmacogenetics, distinguishing between first prescription and monitoring of treatments, drawing inspiration from the measures recently taken to combat antibiotic resistance (e.g. rapid strep test for tonsillitis or...
Antibiotic resistance is a major concern for public and environmental health. The role played by the environment in disseminating resistance is increasingly considered, as well as its capacity for mitigation. We reviewed the literature on strategies to control dissemination of antibiotic-resistant bacteria...
Designing drugs to combat antibiotic resistance Developing small molecules for neurodegenerative diseases Role of medicinal chemistry in vaccine development Drug design strategies for metabolic disorders Medicinal chemistry in personalized medicine Therapeutic potential of synthetic biologics ...