Learn the difference between positive and negative feedback. Understand what is positive feedback in biology through the use of some positive...
A feedback mechanism accelerates or inhibits a process. The feedback mechanism among most of the hormones is a negative feedback loop. It occurs when the original effect of the stimulus is reduced by the output.
the connection between PFKP and the MAPK pathway has been implicated in previous studies. For instance, two independent studies have shown that reduced PFKP expression can attenuate p-ERK1/2 levels in triple-negative breast cancer cell lines and ovarian cancer...
a smooth muscle cell-like phenotype presumed to be highly secretory10and contractile11,12,13. Myofibroblasts are most often identified in vitro by the de novo assembly of alpha-smooth muscle actin (α-SMA) stress fibers14,15,16, although recent research has shown that α-...
haematopoiesis preceded the acquisition of the Ph chromosome– In many ways, the function of the JAK2-V617F in Ph-negative at least in some patients – and implied that molecular abnormal- ities might precede the acquisition of BCR-ABL1.3,4 CMD resembles that of BCR-ABL1 in CML, but with...
Furthermore, we found that the VTA-BLA-NAc circuit is a positive feedback loop. Blocking the projections from the BLA to the NAc associated with sex reward increases the excitability of VTA GABAergic neurons and decreases the excitability of VTA dopaminergic neurons, while activating this pathway...
Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation Author links open overlay panelSivareddy Kotla a 1, Aijun ...
Overall, this work reveals the critical role of MSCs in the glioma microenvironment as signal multipliers to enhance immunosuppressive signaling of glioma exosomes, and disrupting the positive feedback loop in MSCs with modified Dex could improve PD-1 blockade therapy. ...
The above results depicted a positive feedback loop between IGF2BP2 and SLC7A5, which could be validated by LUAD tissue microarray as the expression levels of IGF2BP2 and SLC7A5 were positively correlated (Supplementary Fig. 3A-C). We next assessed whether this loop participated in lung ca...
feedback information from emotional changes. Thus, an ACCGlu–VTAGABA–VTADA–ACCGlupositive-feedback loop mediates the progression to and maintenance of persistent pain and comorbid anxiodepressive-like behavior. Disruption of this feedback loop relieves hyperalgesia and anxiodepressive-like behavior in...