IL-6 dramatically induced the expression of TWIST1 and SNAIL1 via STAT3 activation, leading to the initiation of an EMT. TWIST1, in turn, stimulated production of soluble IL-6, thereby generating a positive feedback loop that maintained the mesenchymal...
This suggests that differential regulation of secreted glycoproteins and integrins direct actin cytoskeleton dynamics through focal adhesion complexes to generate a YAP positive feedback loop during collective invasion. The absence of distinct migratory or invasion signatures in single cell invasion using ...
Smad proteins mediate the transforming growth factor β responses. C-terminal phosphorylation of R-Smads leads to the recruitment of Smad4 and the formation of active signaling complexes. We investigated the mechanism of phosphorylation-induced Smad comp
SARS-CoV-2 is an enveloped betacoronavirus with positive, single-stranded genomic RNA, and is the causative agent of COVID-19. Our understanding of molecular events responsible for the expression of coronavirus proteins has recently been extended to SARS-CoV-21,2,3,4. However, knowledge of the...