Learn the difference between positive and negative feedback. Understand what is positive feedback in biology through the use of some positive...
The oxidation of thiols by 1 that is catalyzed by 2 provides a negative feedback from thiol’s production because of the positive dependence of the oxidation rate from the thiol concentration; however, it is not a negative feedback loop because inhibitor species 1 and 2 are not produced by ...
We have detailed how FLTs can result in the emergence of pathophysiological positive feedback loops which drive abnormal elevations in CRH, cortisol, pro-inflammatory cytokines and potentially damaging products of the KP. The effects of these mediators cascade, disrupting the normal function of ...
In the current work, we analyzed how the enterocytes regulate retinoid concentrations in this negative feedback loop and adapt them to the bodily requirement. We demonstrate in mouse models that the catalytic activity of LRAT in enterocytes is central to the control of this lipid-based signaling ...
it is likely that E2 action on ER+astrocytes influences multiple steps in the brain colonization cascade. ERα+reactive astrocytes associated with late BM increased in E2-treated mice compared to OVX-mice, suggesting the existence of a positive feedback loop between E2 and ERs in these cells. ...
the triple-inhibitor treated CD24+/CD44+double positive cells significantly reverted back to CD24−/CD44+stem-like cell populations, however cells without PDGF-BB stimulation died in culture (Fig.4g, h, Additional file7: Figure S6E). Moreover, PDGF-BB stimulation also rescued apoptotic phenoty...
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer. Oncogene 2015;34:3968–76. Article CAS PubMed Google Scholar Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, et al. P-Rex1 is required for ...
Briefly, criteria for inclusion of gene–gene pairs are the following: Individual P value of correlation within each group is o0.3; combined fisher P value of all groups o0.01; the sign of correlation coefficients in four mouse strain groups should be consistent (all positive correlation or all...
GγH2AX-positive cells in tumor sections were quantified using FIJI. Significance was calculated using one-way ANOVA followed by Tukey multiple comparisons test, ***p < 0.001, ****p < 0.0001. Full size image MLK4 regulates ATM activation and downstream DNA damage response signaling in...
Doing this for every pixel yields an effective spatial pattern where each pixel value, which can be positive or negative, measures how well the contrast sequence at the corresponding pixel matched the preferred temporal contrast sequence of the cell. To reduce the analyzed spatial region to the ...