Learn the difference between positive and negative feedback. Understand what is positive feedback in biology through the use of some positive...
The physiological transitions brought about by chronic stress and which ultimately manifest as MDD are reliant on the disruption of negative feedback loops that are normally involved inhomeostasis. We have detailed how FLTs can result in the emergence of pathophysiological positive feedback loops which...
The oxidation of thiols by 1 that is catalyzed by 2 provides a negative feedback from thiol’s production because of the positive dependence of the oxidation rate from the thiol concentration; however, it is not a negative feedback loop because inhibitor species 1 and 2 are not produced by ...
Circadian clocks control a wide variety of physiological, biochemical, and behavioral processes in most eukaryotes and certain prokaryotes. At the molecular level, circadian systems are composed of positive and negative arms and the latter repress their own expression through inhibiting the positive arm....
1,2,3 At the molecular level, circadian clocks in both fungal and animal cells are regulated by a transcription/translation negative feedback loop (TTFL).4,5 To complete a circadian cycle, the positive arm of the TTFL transcriptionally activates the negative arm, which in turn acts back on ...
the triple-inhibitor treated CD24+/CD44+double positive cells significantly reverted back to CD24−/CD44+stem-like cell populations, however cells without PDGF-BB stimulation died in culture (Fig.4g, h, Additional file7: Figure S6E). Moreover, PDGF-BB stimulation also rescued apoptotic phenoty...
it is likely that E2 action on ER+astrocytes influences multiple steps in the brain colonization cascade. ERα+reactive astrocytes associated with late BM increased in E2-treated mice compared to OVX-mice, suggesting the existence of a positive feedback loop between E2 and ERs in these cells. ...
Briefly, criteria for inclusion of gene–gene pairs are the following: Individual P value of correlation within each group is o0.3; combined fisher P value of all groups o0.01; the sign of correlation coefficients in four mouse strain groups should be consistent (all positive correlation or all...
GγH2AX-positive cells in tumor sections were quantified using FIJI. Significance was calculated using one-way ANOVA followed by Tukey multiple comparisons test, ***p < 0.001, ****p < 0.0001. Full size image MLK4 regulates ATM activation and downstream DNA damage response signaling in...
We have determined that expression of the pseudokinase NRBP1 positively associates with poor prognosis in triple negative breast cancer (TNBC) and is required for efficient migration, invasion and proliferation of TNBC cells in culture as well as growth