Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNAI A small RNA accumulating late in adenovirus infection is required for efficient protein synthesis, although not specifically for the translation of viral p... PA Reichel,WC Merrick,J Siekierka,... - 《Nature》...
Barker MM , Gaal T , Gourse RL ( 2001 ) Mechanism of regulation of transcription initiation by ppGpp. II. Models for positive control based on properties of RNAP mutants and competition for rnap . J Mol Biol 305 : 689 – 702Barker MM , Gaal T and Gourse RL ( 2001a ) Mechanism of...
Positive feedback regulation of lncRNA PVT1 and HIF2α contributes to clear cell renal cell carcinoma tumorigenesis and metastasisMing-xiao Zhang, Li-zhen Zhang, Liang-min Fu, Hao-hua Yao, Lei Tan, Zi-hao Feng, Jia-ying Li, Jun Lu, Yi-hui Pan, Guan-nan Shu, Peng-ju...
Our results suggest that lethality may not be caused by a direct effect on transcription of a set of key genes or pathways. Instead, we propose that rather than a specific action of a tTAV protein, it is the stochastic transcriptional effects specific to each insertion site that contribute ...
Small non-coding RNA RyhB is a key regulator of iron homeostasis in bacteria by sensing iron availability in the environment. Although RyhB is known to influence bacterial virulence by interacting with iron metabolism related regulators, its interaction
cDNAs for transfection in plasmids were obtained by reverse transcription of total RNA from HEK293T and THP-1 cells. The cDNAs were amplified using specific primers before sub-cloning the PCR products into p3 × Flag-CMV-7.1, pCMV-Myc, and pCDNA3.1 vectors. HA-tagged ubiquitin was provided ...
[88]. Here, we suggest that the temperature-associated structural stabilities, including the stability of DNA double helix, the stability of the transient DNA-RNA duplex during transcription, and maybe the stability of the possible secondary structures of mature mRNA [1], might be another non...
These can play roles in the regulation of viral gene expression and RNA synthesis. The 5′-UTRs perform an important role in facilitating translation of viral RNA by the host cell ribosomes and may contain sequences that enhance translation of viral RNA, presumably to outcompete cellular mR...
Importantly, we demonstrate in vivo relevance for both kinases in the regulation of basal mitophagy. Knockdown of GAK homologue (gakh-1) in C. elegans or knockout of PRKCD homologues in zebrafish led to significant inhibition of basal mitophagy, highlighting the evolutionary relevance of these ...
In regard to melanocytes, which can directly affect repigmentation after grafting, GSVA (Gene set variation analysis) using Reactome and GO database showed that pathways including “melanin biosynthesis”, “PI3K-AKT signaling”, “cell-cell adhesion”, and “positive regulation of melanocyte different...