PLX5622 in AIN-76A Diet (1200 ppm) 每 Kg 饲料中包含 1200 mg PLX5622，可用于小胶质细胞的清除...
饮食引起的肥胖(40-60% kcal 来自脂肪)/Diet-induced obesity(40-60% kcal from fat) 高碳水化合物(果糖、蔗糖)/High carbohydrate(fructose, sucrose) 氯化钠调整/NaCl adjusted NAFLD 和 NASH 铜宗脱髓鞘/Cuprizone demyelination 控制营养 维生素/Vitaminadjusted ...
In Vivo: PLX5622 (1.2 g/kg; diet; for 14 days) can fully deplete CNS microglia. PLX5622 (oral gavage; 65 mg/kg/day; for 14 days) causes paw withdrawal threshold high in males C57BL/6 mice (10-12 weeks old, 20-25 g), indicating that PLX5622 prevents the development of injury-as...
PLX5622 (1200 ppm; chow; for 3 weeks or 3 days; adult C57/Bl6 wild type mice) leads to around 80% of microglia lost after 3 days of treatment and a 99% microglia loss after 3 weeks of treatment. PLX5622 (adult C57/Bl6 wild type mice aged 3 months; diet for 3 weeks) decreases ...
Both dosing strategies cause a decrease of microglia population in the adult murine brain resulting in 40% loss of microglia after low-dose (300 mg/kg) and 80% loss of microglia after high-dose (1200 mg/kg) PLX5622 diet [28]. Moreover, this compound has been shown to improve disease-...
PLX5622是一种针对CSF1R（巨噬细胞集落刺激因子1受体）的抑制剂，它用于小胶质细胞（microglia）的清除...
(adult C57/Bl6 wild type mice aged 3 months; diet for 3 weeks) reduces microglia in cortex, striatum, cerebellum and hippocampus [4]. PLX5622 (50 mg/kg; intraperitoneal injection; once (neonatal rat) or twice (adult rat) a day; for a total of 14 days) hemifumarate depletes microglia ...
Once the PLX5622 diet was removed, microglia repopulated the postnatal brain within 7days and did not appear to repopulate from Nestin+precursors. Embryonic microglia depletion also resulted in a decreased litter size, as well as an increase in the number of pups that died within the first two...
(adult C57/Bl6 wild type mice aged 3 months; diet for 3 weeks) reduces microglia in cortex, striatum, cerebellum and hippocampus [4]. PLX5622 (50 mg/kg; intraperitoneal injection; once (neonatal rat) or twice (adult rat) a day; for a total of 14 days) hemifumarate depletes microglia ...
The small molecule PLX5622, a highly selective inhibitor of CSF1R kinase, has been used to deplete microglia and, thereby, alter energy intake and expenditure in high-fat-diet (HFD)-fed mice [9, 10]. Recent data suggest that the effect of PLX5622 is not restricted to microglia and that...