PLX5622 in AIN-76A Diet (1200 ppm) 每 Kg 饲料中包含 1200 mg PLX5622，可用于小胶质细胞的清除...
PLX5622 (formulated in AIN-76A standard chow at 1200 mg/kg; for 28 days) leads to reduction in microglia throughout the CNS in 14-month-old 5xfAD mice[6].Pharmacokinetics of PLX5622 in preclinical species[1] Species IV PO (gavage) Dose(mg/kg) AUC0-∞(ng hr/mL) CL(mL/min/kg) ...
PLX5622 (formulated in AIN-76A standard chow at 1200 mg/kg; for 28 days) leads to reduction in microglia throughout the CNS in 14-month-old 5xfAD mice. Preparation of gavage dosing suspensions for PLX5622. PLX5622 is dissolved in DMSO at a concentration that is 20x the final dosing solu...
尽管PLX5622有着上述优势，但请注意使用CSF1R抑制剂要谨慎，因为小胶质细胞在中枢神经系统中扮演着重要的...
(A single daily injection of 0.65% PLX5622 suspended in 5% dimethyl sulfoxide and 20% Kolliphor RH40 in 0.01 M PBS is sufficient for neonatal microglia depletion, adult depletion requires injections twice daily) [5]. PLX5622 (formulated in AIN-76A standard chow at 1200 mg/kg; for 28 days...
(A single daily injection of 0.65% PLX5622 suspended in 5% dimethyl sulfoxide and 20% Kolliphor RH40 in 0.01 M PBS is sufficient for neonatal microglia depletion, adult depletion requires injections twice daily) [5]. PLX5622 (formulated in AIN-76A standard chow at 1200 mg/kg; for 28 days...