PLX5622 (formulated in AIN-76A standard chow at 1200 mg/kg; for 28 days) leads to reduction in microglia throughout the CNS in 14-month-old 5xfAD mice. Preparation of gavage dosing suspensions for PLX5622. PLX5622 is dissolved in DMSO at a concentration that is 20x the final dosing solu...
1B). We applied PLX6522 or AIN control diet seven days before PCI induction or LPS injection in the following experiments. As expected, when compared to previous studies using PCI in C57BL/6J mice, PCI-induced polymicrobial sepsis resulted in an overall survival of ~ 60% in AIN ...
(A single daily injection of 0.65% PLX5622 suspended in 5% dimethyl sulfoxide and 20% Kolliphor RH40 in 0.01 M PBS is sufficient for neonatal microglia depletion, adult depletion requires injections twice daily) [5]. PLX5622 (formulated in AIN-76A standard chow at 1200 mg/kg; for 28 days...
(A single daily injection of 0.65% PLX5622 suspended in 5% dimethyl sulfoxide and 20% Kolliphor RH40 in 0.01 M PBS is sufficient for neonatal microglia depletion, adult depletion requires injections twice daily) [5]. PLX5622 (formulated in AIN-76A standard chow at 1200 mg/kg; for 28 days...