The generation of functional skeletal muscle tissues from human pluripotent stem cells (hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) via transient overexpression of Pax7 in paraxial mesoderm cells differentiated
Transplantation of derivative retinal organoids from chemically induced pluripotent stem cells restored visual function Article Open access 27 December 2024 Introduction Rod and cone photoreceptors, which comprise the retinal outer nuclear layer (ONL), are the light sensing cells of the eye. They con...
Thus, ESCs derived from parthenogenetic embryos are capable of differentiation to many lineages; however, it is still unclear whether homozygosity in some regions of the genome and/or lack of paternal imprinting might disrupt cell function. Embryonic Germ Cells Primordial germ cells have been shown ...
Therefore, this study showcases a new approach for enriching and enhancing the function of induced pluripotent stem (iPS) cell‐derived ECs from a very small amount of blood through ESM1 signaling, which greatly enhances their functionality and increases their therapeutic potential. Stem Cells 2019;...
Gene modification of cells prior to their transplantation, especially stem cells, enhances their survival and increases their function in cell therapy. Lik... MI Phillips,YL Tang - 《Advanced Drug Delivery Reviews》 被引量: 121发表: 2008年 Molecular stages of rapid and uniform neuralization of ...
Technical advances in generating and phenotyping cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are now driving their wider acceptance as in v
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells Genes Dev., 25 (2011), pp. 679-684 CrossrefView in ScopusGoogle Scholar Xu et al., 2011 Y. Xu, F. Wu, L. Tan, L. Kong, L. Xiong, J. Den...
A double fail-safe approach to prevent tumorigenesis and select pancreatic beta cells from human embryonic stem cells. Stem Cell Rep. 12:611–623, 2019. Article Google Scholar Simon, M. C., and B. Keith. The role of oxygen availability in embryonic development and stem cell function. Nat...
A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the 'Warburg effect', which is also observed in primed human pluripotent stem cells (hPSCs). Here, we report that downregulation of SIRT2 and upregulation of SIR...
Human Embryonic Stem Cell–Derived Cells Rescue Visual Function in Dystrophic RCS Rats Embryonic stem cells promise to provide a well-characterized and reproducible source of replacement tissue for human clinical studies. An early potential a... RD Lund,S Wang,I Klimanskaya,... - 《Cloning Stem...