Hie researched applications are primarily in the therapeutic field, such as the treatment of inhalation diseases, inflammations, cancer, immune diseases, genetic disorders, the regulation of vasodilatation or the surface coating of medical implants with biocompatible PLGA nanoparticles.Cordin Arpagaus...
Nanoparticles were prepared by double emulsion solvent evaporation method followed by lyophilized to obtain inhalation powder form. The prepared nanoparticles (NPs) were evaluated for their physicochemical characteristic along with DSC, FTIR, and SEM. The anticancer activity of SB-loaded NPs was assessed...
Although not differing in encapsulation efficiency, the OVA release profile of PLGA-MP was superior compared to nanoparticles (Supplementary Fig. 1a, b). The used PLGA type RG502H almost completely degrades within 30 days as visualized by fluorescent MP-OVA/Rib in vivo (Fig. 2c). The ...
Polymeric micelles are self-assembling nanoparticles with a hydrophobic core and a hydrophilic shell [22]. As a novel drug carrier, the characteristics of polymer micelles including wide drug-loading range, stable structure, long residence time, and low side effects [23]. We use polymer micelles ...
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2012). Recently, PLGA nanoparticles (NPs) carrying multiple ligands have been investigated to maximize tumour-targeting efficiency. These PLGA NPs can passively target delivery to tumours through enhanced permeability and retention (EPR) effect, and actively target delivery to tumours based on ligand–...
The formulated nanoparticles had a mean particle size of 307.50±9.54nm, PDI was 0.136±0.02, zeta potential about -11.3±0.4mV, decent entrapment efficiency (55.46±2.40%), drug loading (9.05±0.22%), and excellent flowability. FTIR confirmed that NAC and PLGA were compatible with each other....
Formulated AFA nanoparticles (AFA-NP) were evaluated for physicochemical properties (particle size: 180.2 ± 15.6 nm, zeta potential: 23.1 ± 0.2 mV, % entrapment efficiency: 34.4 ± 2.3%), formulation stability, in-vitro aerosol deposition behavior, and anticancer efficacy. Stability studies ...
Foged, Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation, J. Control. Rel. 142 (2010) 138-145.Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation. Jensen, Ditte Marie Krohn,Cun, Dongmei,Maltesen, Morten Jonas,Frokjaer, Sven,Nielsen, Hanne Mrck,...
Encapsulation in the form of nanoparticles or microspheres is considered an effective drug delivery method for proteins/peptides to protect their bioactivities, enhance the therapeutic efficiency, and reduce drug side-effects as well. In this study, prolonged release of KSL-W to the targeted diseased...