H., Juxtaglomerular cell CaSR stimulation decreases renin release via activation of the PLC/IP3 pathway and the ryanodine receptor.American Journal of Physiology-Renal Physiology, 304(3), F248-F256, 2013Ortiz-Capisano MC, Reddy M, Mendez M, Garvin JL, Beierwaltes WH. Juxtaglomerular cell ...
T淋巴细胞CaSR的作用及其.ij PLC.IP3通路和TRPC通道的关系 PLC—DAG传导通路激活开放,并非由钙库调节。但是在单个细胞水平的研究中 fM】,TRPC5也会以钙库操纵性钙内流的方式参与调节[Ca2+]i,究其原因,可能是 出于当TRPC5处于不同的表达水平时,对钙库的敏感度也不同。 有研究显示…】,TRPC6是以受体偶联PLC...
stimuli, such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCg. Activated PLCg catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol ...
Emerging beyond the conventional transfemoral pathway, transaxillary/subclavian and transcaval approaches represent additional choices for intervention. Implementing these alternative techniques necessitates operators with advanced capabilities and the cooperation of a dedicated multidisciplinary team, with dedicated ...
A potential explanation for the agonist-specific [Ca2+]c spike shapes is differential modulation of the generation and/or metabolism of IP3 by distinct GPCRs. An additional component of the Gq-linked PLC pathway is the generation of diacylglycerol and activation of PKC, concurrent with the product...
Both DAG/PKCδ and CaMK IIβ triggered protein kinase B (Akt)/mammalian target of rapamycin (mTOR)/S6 pathway to regulate protein synthesis. The data indicate that DAG/PKCδ and IP3/Ca2+/CaMK IIβ operate in parallel to each other in PLCγ1-driven cell proliferation and migration of ...
Except for the finding of the PLC/IP3/CRAC channel signaling cascade as a “forward” pathway by which c-MWCNTs induce macrophage migration, we also identified the involvement of the KCa3.1 channel, which may potentially act as a “feedback” signal in the c-MWCNT-induced behavioral event of...
UTP经PLC-IP3信号通路调控猪冠状动脉平滑肌细胞自发性瞬时外向电流.pdf,维普资讯 生理学报ActaPhysiologicaSinica,February25,2008,60(1):65—73 http://www.actaps.corn.ca UTP经PLC.IP3信号通路调控猪冠状动脉平滑肌细胞 自发性 瞬时外 向电流 李鹏云,曾晓荣
Use of Ca2+channel blockers and kinase inhibitors demonstrated that Tg-induced myometrial contractions are mediated by activation of the phospholipase C (PLC)-inositol triphosphate (IP3) signaling pathway, resulting in increased MLC20 phosphorylation. Furthermore, Y27632, a specific inhibitor of Rho...
【摘要】磷脂酰肌醇特异性磷脂酶C(PI-PLC)能够水解植物细胞中的磷脂生成三磷酸肌醇(IP3),而IP3可以促进花粉管细胞中Ca2+的释放,从而促进植物花粉管生长.深入了解PI-PLC调节植物生长的作用,从而为PI-PLC基因在植物生长中的进一步研究提供参考,从PI-PLC基因的定位与结构、PI-PLC与质膜的结合方式、IP3促进Ca2+释放的...