Baylis HA, Vazquez-Manrique RP (2012) Genetic analysis of IP3 and calcium signalling pathways in C. elegans. Biochim Biophys Acta 1820: 1253-1268Baylis H. A., Vázquez-Manrique R. P. (2012). Genetic analysis of IP(3) and calcium signalling pathways in C. elegans . Biochim. Biophys. ...
calcium channels and the physiological stimuli that control these channels or are communicated through them. A discussion of the role of calcium as an intracellular second messenger and the pathophysiology of renal calcium dysregulation, as well as a summary of gaps in knowledge and future prospects,...
To confirm that ERK1,2 and PLC signalling were mediated via CaSR, HAoSMC were transfected with CaSR siRNA. CaSR knockdown resulted in lower ERK1,2 neomycin response and IP3 production (p<0.01). Neomycin increased HAoSMC proliferation >3-fold, which was reduced in CaSR knockdown cells (p...
Calcium signaling in vertebrate embryonic patterning and morphogenesis Diane C.Slusarski,FranciscoPelegri, inDevelopmental Biology, 2007 Signaling pathwaysthat rely on the controlled release and/or accumulation ofcalcium ionsare important in a variety of developmental events in the vertebrate embryo, aff...
Nowadays, it is acknowledged that calcium is the most ubiquitous intracellular signaling molecule and that the concentration of Ca2+ ions is under very tight and dynamic control in all major cell compartments (cytoplasm, nucleus, endoplasmic reticulum, mitochondria). In each compartment, this control ...
IGF‐1 Induces IP3‐dependent Calcium Signal Involved in the Regulation of Myostatin Gene Expression Mediated by NFAT During Myoblast Differentiation N., Osorio-Fuentealba, C., Jaimovich, E., and Molina, A. (2013) IGF-1 induces IP3-dependent calcium signal involved in the regulation of myostatin...
In all, 0.65 mM CaCl2 was then added to induce the influx of ER calcium. After a steady-state was achieved, 1 µM IP3 was introduced to evoke ER calcium release through IP3R. e Measurement of ER calcium release in WT (black, n = 72 cells) and Parkin KO (red, n ...
This study uncovered the antagonistic functions of synaptic and extrasynaptic NMDARs in the regulation of CREB-mediated transcription and cell survival and/or death pathways. CAS PubMed Google Scholar Zhang, S.-J. et al. Decoding NMDA receptor signaling: identification of genomic programs ...
NF-kappaB activation is mediated by IkappaBalpha degradation and p65 translocation to the nucleus. Partial blockade by N-acetyl-l-cysteine, a general antioxidant, suggests the participation of reactive oxygen species. Calcium-dependent signaling pathways such as those linked to calcineurin and PKC ...
Cells employ a diverse range of messengers and channels to access these sources [3]. For mobilising Ca2+ stores, inositol 1,4,5-trisphosphate (IP3) receptors are a principal route in almost all cell types. The release of Ca2+ via IP3 receptors stimulates activities critical for life, such ...