platelet transfusionthrombocytopeniaBackground & objectives: The indications for platelet transfusion in dengue fever are clearly defined in World Health Organization (WHO) guidelines (2011) for dengue fever, but physicians face practical difficulty in its implementation in an epidemic setting. On one ...
Readers are referred to linked BSH guidelines on transfusion support in children and the use of viscoelastic haemostatic assays (VHAs).7, 8 Major haemorrhage is a clinical emergency that results in morbidity and mortality: practice guidance is important to reduce these risks. Delayed recognition of...
血小板输注指南GUIDELINESOFPLATELETTRANSFUSIONS 华西医院血液科李建军 血小板 •由骨髓中的巨核细胞产生。•生理作用：止血 维护血管内皮的完整性；粘附、聚集、释放形成血小板血栓止血；促凝功能。血小板的制备 •方法:手工法机采法浓缩血小板悬液（4.8x1010）单采血小板（2.5x1011）输注止血效果二者相似。•...
•Prophylactic platelet transfusions for children undergoing cancer treatment are not well characterized and require further investigation.•The effect of routine platelet transfusion in pediatric cardiac surgery on postoperative outcome is unknown.•The determination of platelet count threshold before vario...
For children, an approximate equivalent is an absolute platelet count increment of 3500/microL per meter squared per transfused unit. A diagnosis of refractoriness should be entertained only when at least two consecutiveABO-compatibletransfusions, stored le...
Guidelines for the use of platelet transfusions. Br J Haematol. 2017;176(3):365–94. Article Google Scholar Zychowicz A, Radkowiak D, Lasek A, Malczak P, Witowski J, Major P, Strzalka M, Kulawik J, Budzynski A, Pedziwiatr M. Laparoscopic splenectomy for immune thrombocytopenia in ...
She had an extensive bleeding history, with epistaxis, menorrhagia and postoperative bleeding requiring multiple previous transfusions. Repeat haemostatic workup in our centre revealed normal Von Willebrand levels but abnormal platelet aggregation consistent with Glanzmann thrombasthenia. Antibody screening ...
children [38]. Our understanding of platelet biology, storage methods, and transfusion techniques has significantly improved, leading to the establishment of standardized protocols for PC production from allogeneic donors and evidence-based transfusion therapy [32]. Various international guidelines and ...
All procedures were performed in accordance with the approved guidelines. Venous blood was collected into 3.2% trisodium citrate tubes (9:1) and immediately centrifuged at room temperature at 200×g for 10 min to obtain platelet-rich plasma (PRP). Platelets from PRP were isolated by gel ...
Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, but their contributions to rapid clinical deterioration and dysregulated inflammation have not been defined. Here, we show that the incidence of thrombocytopathy and