In the ALFA+ cohort, all tested plasma biomarkers (p-tau181, p-tau217, p-tau231, GFAP, NfL and Aβ42/40) were significantly changed in preclinical Alzheimer’s disease. However, plasma p-tau231 reached abnormal levels with the lowest Aβ burden. Plasma p-tau231 and p-tau217 had the...
Plasma p‐tau231 and p‐tau217 inform on tau tangles aggregation in cognitively impaired individualsdoi:10.1002/alz.13393Ferreira, Pamela C. L.Therriault, JosephTissot, CécileFerrari‐Souza, Joo PedroBenedet, Andréa L.Povala, GuilhermeBellaver, Bruna...
As a growing number of studies demonstrated the great promise of plasma p-tau231 and p-tau217 in the early identification of AD pathophysiology [12, 21,22,23], their inclusion in the analysis may yield intriguing results. However, limited by the current technical conditions, we are unable ...
Analysis of plasma p-tau217 was performed using the Meso Scale Discovery (MSD) platform at Eli Lilly and Company [21, 23]. In the BioFINDER, plasma levels of Aβ42, Aβ40 and p-tau217 were measured using the same assays as in the J-TRC at Shimadzu Techno-Research (Aβ42 and A...
Plasma pTau217 demonstrates higher accuracy for Aβ and tau positivity compared to other plasma biomarkers and their combinations eFigure 9. Correlations of ALZpath pTau217 with Aβ and tau PET eFigure 10. Correlations of ALZpath pTau217 with CSF pTau217 eFigure 11. Binary and three-range...
In the CU, amyloid-negative (A–) subset, plasma p-tau217 levels increased modestly with age but were unaffected by body mass index and kidney function. In the whole sample, average p-tau217 change rates were higher in those who were A+ (e...
Ashton NJ, Janelidze S, Mattsson-Carlgren N et al (2022) Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring. Nat Med. https://doi.org/10.1038/s41591-022-02074-w Article PubMed PubMed Central Google Scholar Teunissen CE, Ver...
Phosphorylated tau (p-tau) and amyloid beta (Aβ) in human plasma may provide an affordable and minimally invasive method to evaluate Alzheimer’s disease (AD) pathophysiology. The medial temporal lobe (MTL) is susceptible to changes in structural integr
The third data point for the topmost individual coincided with a cold (R. P. Tracy, personal communication). A more sophisticated approach, but one that still compares an individual to external populations, is to assign a protein level that best distinguishes people who do not have a specific...
specificity to AD versus non-AD neurodegenerative diseases, and will be extremely important to inform on clinical diagnosis and eligibility for therapies that have recently been approved. This review provides an update on the diagnostic and prognostic performances of plasma p-tau181, p-tau217 and p...