Plasma pTau217: single vs multiple phospho‐site assaysdoi:10.1002/alz.082953Benedet, Andrea L.Pola, IlariaTriana‐Baltzer, GallenMolfetta, Guglielmo DiArslan, BurakRahmouni, NesrineTissot, CécileTherriault, JosephServaes, StijnPascoal, Tharick A....
Plasma p-tau217 has emerged as the most promising blood-based marker (BBM) for the detection of Alzheimer Disease (AD) pathology, yet few studies have evaluated plasma p-tau217 performance in memory clinic settings. We examined the performance of plasma p-tau217 for the detection of AD using...
In the ALFA+ cohort, all tested plasma biomarkers (p-tau181, p-tau217, p-tau231, GFAP, NfL and Aβ42/40) were significantly changed in preclinical Alzheimer’s disease. However, plasma p-tau231 reached abnormal levels with the lowest Aβ burden. Plasma p-tau231 and p-tau217 had the...
Decreased Aβ42/Aβ40 ratio and increased p‐tau217 and p‐tau181 were associated with subsequent AD diagnosis. Discussion Blood‐based AD biomarker concentrations are associated with pathological and clinical diagnoses and can predict future development...
We measured plasma levels of tau phosphorylated at threonine 217 (P‐tau217) in the prospective Swedish BioFINDER (BF) I and II studies (n=1057). BF㊣I included cognitively unimpaired individuals (CU, n=275) and patients with mild cognitive impairment (MCI, n=161), AD dementia (n=114)...
Plasma phosphorylated tau 181 (P-tau181) and 217 (P-tau217) are indicators of both amyloid and tau pathology in clinical settings, but their performance in heterogeneous community-based populations is unclear. We examined P-tau181 and P-tau217 (n = 1,329, aged 30–98 years), in...
This cross-sectional study compares the accuracy of plasma tau phosphorylated at threonine 217 (P-tau217) levels vs other plasma-, MRI-, CSF-, and
Association Between Plasma and Cerebrospinal Fluid (CSF) Tau Phosphorylated at Threonine 217 (P-tau 217) View LargeDownload A and B, Association between plasma and CSF P-tau217 in cognitively unimpaired participants (amyloid-β positron emission tomography negative [Aβ-PET–], n = 252; A...
Combination of plasma Aβ-related biomarkers and p-tau217 exhibits high performance when predicting Aβ-PET positivity. Adding basic clinical information (i.e., age, sex, APOEε genotype) improved the prediction in preclinical AD, but not in prodromal AD. Combination of Aβ-related biomarkers ...
In the CU, amyloid-negative (A–) subset, plasma p-tau217 levels increased modestly with age but were unaffected by body mass index and kidney function. In the whole sample, average p-tau217 change rates were higher in those who were A+ (e...