Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). We included 366 adults with DS (240 ...
Conclusion: These findings indicate that plasma p-tau181 concentrations likely relate to brain injury, with the highest levels in patients with neuroimaging evidence of injury. Future research is needed to replicate and validate this protein assay's performance as a possible...
Plasma phosphorylated tau 181 (P-tau181) and 217 (P-tau217) are indicators of both amyloid and tau pathology in clinical settings, but their performance in heterogeneous community-based populations is unclear. We examined P-tau181 and P-tau217 (n = 1,329, aged 30–98 years), in...
Age- and sex-adjusted associations of plasma p-tau181 and NfL change with hypometabolism progression are shown at the voxel (upper row) and Alzheimer disease (AD) meta–region of interest (ROI) level (bottom row) in CU (A) and CImp (B) individuals. To account for the difference in ...
This exploratory pilot study warrants further large-scale and well-controlled studies to validate the usefulness of plasma p-tau181 as an urgently needed surrogate marker for the diagnosis and disease progression of AD. 展开 关键词: Plasma biomarker, Tau phosphorylated at threonine 181 (p-tau181)...
TABLE 21.1.Tau Phosphorylation, Anti-tau antibodies, and Kinasesa Ser/Thr sitesAD-type AbAntibodiesCaMKIICdc2cdk5CKICKIIGSK3MAPKMARKPhKpKApKCSAPK T39+ S46P++ T50P++ T153P++ T181PAT270+++ S184 S188+ S199P++ S202PAT8+++++ T205P+++++ ...
Increased levels of CSF tau and phosphorylated tau (p-tau 181) correlate with memory deficits in mild cognitive impairment - Alzheimer's & Dementia: The Journal of the Alzheimer's Associationdoi:10.1016/j.jalz.2009.04.1185Kanemaru, Kazutomi...
Vanmechelen E., Vanderstichele H., Davidsson P., Van Kerschaver E., Van der Perre B., Sjögren M., et al. (2000) Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization. Neurosci. Lett. 285,...
Furthermore, significant changes in plasma EV biomarkers of P-tau181, Aβ 1–42, and cathepsin were observed in EVs in AD23. EVs have also been shown to carry proteins related to the key pathologies in AD, such as P-tau27and Aβ28. EVs may facilitate the spread of these proteins bet...
To assess plasma phosphorylated tau181 (p-tau181) as a progression biomarker in Alzheimer’s disease (AD), we examined longitudinal plasma p-tau181 of 1184 participants (403 cognitively normal (CN), 560 patients with mild cognitive impairment (MCI), and