Using correlative light and electron microscopy, we further show that IRSp53 ensures the shape and continuity of the opposing plasma membrane of two daughter cells, leading to the formation of a single apical lumen. Genetic removal of IRSp53 results in abnormal renal tubulogenesis, with altered ...
postgerminal center B cell corresponding to a long-lived plasma cell. 3 Intramedullary plasma cells develop karyotypic instability and form immortalized clone(s). As clone numbers increase, a premalignant bone marrow MRD becomes evident. As clonal cells evolve, there is morphological transition with ...
The plasma proteome is highly dynamic and variable, composed of proteins derived from surrounding tissues and cells. To investigate the complex processes that control the composition of the plasma proteome, we developed a mass spectrometry-based proteomi
“Cancer,”“neoplasm,” and “tumor,” used interchangeably herein, refer to cells or tissues that exhibit an aberrant growth phenotype characterized by a significant loss of control of cell proliferation. The methods and compositions of this invention particularly apply to precancerous (i.e., be...
Utilizing 3D Models to Unravel the Dynamics of Myeloma Plasma Cells’ Escape from the Bone Marrow Microenvironment by Stefaan W. Verbruggen 1,2,3,*, Ciara L. Freeman 4,† and Fiona E. Freeman 5,6,7,8,9,*,† 1 Digital Environment Research Institute, Queen Mary University of Lo...
Cell-free DNA (cfDNA) is released into body fluids from cells of various tissues through different processes [1]. The cell-type specific methylation signature mostly occurring at CpG sites is preserved in cfDNA, and thus can be utilized to gain information about its tissue of origin (TOO) [...
When low-concentration PRP devices are used to create PR-PRPs, the cell concentration and the number of released matrices bound cells per time unit will be even lower, hence limiting the regenerative potential of the matrix. Table 3. Hematology data from different PRP preparations. A PR-PRP ...
Figure 11 outlines the cell proliferation assay for BMSCs with porous titanium treated with different concentrations of base. Mitochondria in living cells oxidize and reduce the dehydrogenase in cck-8 to form a water-soluble orange-yellow formazan dye, while dead cells do not have this function. ...