Pathology of Plasma Cells and Plasma Cell Disorders Cellular Morphology The key morphological features of a mature plasma cell (also known as a terminally differentiated plasma cell, Marschalko cell, or plasmacyte) are as follows: intensely basophilic cytoplasm due to the high ribonucleoprotein content...
immunohistochemistry, and ELISA. First, we stained postmortem brain tissue sections for Aβ plaques using modified Bielschowsky silver staining [24,25,26,27,28]. To assess the severity of frontal Aβ plaque pathology, we classified plaques as diffuse Aβ plaques (DPs) or neuritic Aβ plaques...
2011,Pathology of the Lungs (Third Edition) BryanCorrinMD FRCPath,Andrew G.NicholsonDM FRCPath Explore book Pathological features Microscopically,plasmacytomasconsist of sheets of plasma cells: many may appear normal but others have multiple nuclei and some show nuclear pleomorphism. The spindle-sha...
The plasma proteome is highly dynamic and variable, composed of proteins derived from surrounding tissues and cells. To investigate the complex processes that control the composition of the plasma proteome, we developed a mass spectrometry-based proteomi
Notes: In the pathology column; WD = well-differentiated grade, Int = intermediate grade, PD = poorly differentiated grade tumours. Marrow negative implies <10% plasma cells in bone marrow, where (a) marrow has been successfully sampled at preferably two separate anatomic sites and (b) ...
cells on pliable matrigel in a matrigel-containing medium that provides the mechanochemical cues for formation of a polarized hollow sphere (cyst). The de-novo apical–basal polarity arises from successive divisions of a single, nonpolarized cyst-forming cell2,3. The first symmetry-breaking event ...
[18F]FDG PET/CT enables the detection of individual or multiple osteolytic bone lesions > 5 mm, a CRAB criterion. In addition, it allows tumor cells and the tumor microenvironment to be identified based on their propensity to consume higher levels of glucose compared to normal bone cells...
Particularly, 3 types of glial cells have been implicated in a complex temporal pattern of glial activation following peripheral nerve injury namely; astrocytes and microglia in the central nervous system (CNS) and satellite glial cells of the trigeminal ganglia and dorsal root ganglion in the ...
Syntaxin 2 labeling also was widely distributed in the IPL and in the cell bodies of amacrine cells, but was more punctate in appearance than labeling for syntaxin 1. There was little labeling for syntaxin 2 in the OPL, similar to syntaxin 1. Labeling for syntaxin 3 was present in the ...
Particulate RNAs released from BC3 cells was incubated in PBS, plasma, or blood for the indicated time, and miR-16 was quantified using TaqMan RT-qPCR. Portions of miR-16 in 2-hour blood samples are likely of whole-blood origin. B: Phenol/chloroform extraction and silica absorption of RNA...