Flow Cytometry in Diagnosis, Prognostication, and Monitoring of Multiple Myeloma and Related Disorders Flow cytometry plays a critical role in the diagnosis, prognostication, therapy response evaluation, and clinical management of plasma cell neoplasms. The ... M Roshal,Q Gao - 《Clinics in Laboratory...
In classical terms, a plasma cell is a terminally differentiated B lymphocyte, and a myeloma cell is its neoplastically transformed progeny. These are simplistic definitions, for plasma cell disorders (PCDs) are a complex group comprising a diverse spectrum of benign conditions to cancers known as...
These studies demonstrated, similar to in vivo observations, that the addition of MSCs within the 3D hydrogel system enhanced MM cell viability [58,62,63] and increased CXCR4 expression on MM cells [62]. The perivascular niche plays a critical role in the myeloma tumour microenvironment, ...