In classical terms, a plasma cell is a terminally differentiated B lymphocyte, and a myeloma cell is its neoplastically transformed progeny. These are simplistic definitions, for plasma cell disorders (PCDs) are a complex group comprising a diverse spect
“Cancer,”“neoplasm,” and “tumor,” used interchangeably herein, refer to cells or tissues that exhibit an aberrant growth phenotype characterized by a significant loss of control of cell proliferation. The methods and compositions of this invention particularly apply to precancerous (i.e., be...
Multiple myeloma (MM) is the second leading haematological malignancy in the United States [1]; a malignant neoplasm of plasma cells, which primarily affects the bone marrow. It remains incurable, with a high preponderance for clonal evolution and progressively shorter responses over time [2,3,4...