in a pattern usually seen in serum amyloid A in the setting of chronic inflammatory diseases,including severe inflammatory bowel disease.Bone marrow biopsy showed kappa-restricted plasma cell neoplasm.CONCLUSION Described is an unusual presentation of primary systemic amyloidosis,highlighting the risk of ...
Abstract Multiple myeloma (MM) is a neoplasm of a terminally differentiated B-cell. Human myeloma cell lines were shown to be suitable model systems for use in various fields of the biological sciences. Within the last 20 years more than 100 cell lines have been established. So-called ‘...
Cell linesEBVMyelomaPlasma CellsMultiple myeloma (MM) is a neoplasm of a terminally differentiated B-cell. Human myeloma cell lines were shown to be suitable model systems for use in various fields of the biological sciences. Within the last 20 years more than 100 cell lines have been ...
CelllinesEBVMyelomaPlasmaCellsMultiple myeloma (MM) is a neoplasm of a terminally differentiated B-cell. Human myeloma cell lines were shown to be suitable model systems for use in various fields of the biological sciences. Within the last 20 years more than 100 cell lines have been established...
DNA, NeoplasmWe found that thapsigargin (Tg), a non-phorbol ester type tumor promoter that specifically inhibits endoplasmic reticulum Ca 2+ -ATPase, transiently increased the level of cytosolic free calcium ([Ca 2+ ] i ) and subsequently induced chromatin condensation, nuclear fragmentation, and ...
Seven years later, the Cleveland group used a complementary approach, checking whether their 240 LGLL patients harbored myeloid neoplasm-acquired mutations. Using next generation sequencing (NGS), they found that the frequency of mutations in STAT3/STAT5b was 39% in patients with LGLL alone and 15...