Plasma Cell LeukemiaMultiple MyelomaIntroduction: Plasma cell leukemia (PL) is a rare lymphoproliferative disorder characterized by the monoclonal proliferation of plasma cells in the marrow and blood peripheral. It is defined by a blood plasmacytosis greater than 2 G/l or a plasma cell level greate...
Plasma cell leukemia (PCL) is a rare and aggressive form of plasma cell dyscrasia, often presenting as a variant of multiple myeloma (MM). It is characterized by the presence of ≥5% circulating plasma cells in peripheral blood, either as a primary or secondary manifestation of MM. METHODS...
Primary plasma cell leukemia (pPCL) is the most aggressive form of the plasma cell dyscrasias. It is defined by the presence of > 2 × 109/L peripheral blood plasma cells or plasmacytosis accounting for > 20% of the differential white cell count, and does not arise from preexisting multipl...
Leukemia (leukapheresis) (for acute debulking only) including mantle cell lymphoma (mantle cell leukemia) if white blood cells count is greater than 100,000/µL; or Myasthenia gravis, in persons with any of the following: Acute, short-term benefit is critical because of a sudden worsening of...
The current definition of plasma cell leukemia (PCL)— ≥ 20% circulating plasma cells (CPCs) on peripheral smear and plasma cell count ≥ 2 × 109/L—may be too stringent. We reviewed outcomes of 176 multiple myeloma (MM) patients diag
The case was diagnosed as plasma cell leukemia due to the high percentage of plasma cells in the peripheral blood.7 Depending on CD138 for diagnosis of plasma cell neoplasm can also raise some other challenges, such as differential diagnosis of Plasmablastic lymphoma. The latter are usually ...
plasma cell leukemia; CD138 negative; CD4 positive Background Plasma cell leukemia (PCL) is an uncommon and aggressive disease caused by the clonal proliferation of atypical plasma cells with phenotypical abnormalities similar to those seen in multiple myeloma (MM), although at different rates. Here...
Early detection of cancer is vital for the best chance of successful treatment, but half of all cancers are diagnosed at an advanced stage. A simple and reliable blood screening test applied routinely would therefore address a major unmet medical need. T
Peripheral blood and bone marrow smear showed marked plasma cell proliferation mimicking plasma cell leukemia. However, flow cytometric analysis showed that plasma cells were of polyclonal origin and M-protein was not detected by immunofixation of serum protein. Elevations of soluble interleukin 2 ...
https://doi.org/10.1182/blood-2016-01-643569 Article CAS PubMed PubMed Central Google Scholar Insuasti-Beltran G, Gale JM, Wilson CS, Foucar K, Czuchlewski DR (2015) Significance of MYD88 L265P mutation status in the subclassification of low-grade B-cell lymphoma/leukemia. Arch Pathol...