Antibody‐secreting cellBlimp‐1ImmunoglobulinUnfolded protein responseAntibodies are an essential component of our immune system, underpinning the effectiveness of both the primary immune response to microbial pathogens and the protective and long﹍ived immunity against reヽhallenge. All antibodies are ...
plasma cell content also have high IgG expression, potentially as a reflection of plasma cell antibody secretion (Supplementary Fig.1a–b). Additionally, plasma cell anti-tumor activity increases when they colocalize with other lymphocytes into organized cellular aggregates called tertiary lymphoid ...
Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring. Nat. Biotechnol. 35, 977–982 (2017). This work presents a microfluidic system that allows high-throughput screening for antigen-specific antibody-secreting cells, simultaneously measuring the antibody secretion ...
Plasma cells are terminally differentiated B lymphocytes that provide protective immunity through the continuous secretion of antibodies. Antibody-secreting cells develop in secondary lymphoid tissue following antigen stimulation and may enter a short-lived plasma cell population that reside primarily in the ...
Still undefined are the minimal requirements to become a plasma cell and what molecular features make peripheral B cell subsets competent to become antibody-secreting plasma cells. New technologies promise to reveal underlying chromatin configurations that promote efficient antibody secretion. For further ...
Plasma cells operate as factories where large quantities of Ig heavy and light chains are made and assembled into functional antibodies. The finished products are shipped out with impressive efficiency. A major component of the machinery n...
The findings demonstrate that in addition to SNAP23, STX4 is implicated in the antibody secretion by a myeloma cell line and by normal human colon LP-PCs. 展开 关键词: RNAi protein knockdown SNARE immunoglobulin exocytosis DOI: 10.1189/jlb.0113031 被引量: 10 ...
Plasma cell differentiation requires silencing of B cell transcription, while it establishes antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusiv...
Intrinsic Constraint on Plasmablast Growth and Extrinsic Limits of Plasma Cell Survival B cells recruited into splenic antibody responses grow exponentially, either in extrafollicular foci as plasmablasts, or in follicles where they form germi... Sze,D. M.-Y. - 《Journal of Experimental Medicine》...
Piecemeal degranulation is a unique pattern of cell secretion that consists of a slow release of granule contents from cytoplasmic secretory granules, whic... E Crivellato,D Ribatti,F Mallardi,... - 《Anatomical Record》 被引量: 42发表: 2002年 Messenger-mediated control of potassium channels ...