While it may be advisable to minimize the placebo effect in clinical trials in order to estimate the pure effect of the active treatment, acting in the patient's best interest may require maximizing the placebo effect in the usual clinical setting....
Placebo effect in clinical trials involving patients with allergic rhinitis. Interest in understanding the underlying mechanisms of the placebo effect has considerably grown during the last few decades. Studies made in this sense ha... AD Cuvillo,J Sastre,J Bartra,... - Journal of investigational ...
Placebo EffectClinical Trials as TopicStatistics as TopicRandomized Controlled Trials as TopicWe often and wrongly equate the response seen in the placebo arm... E Ernst,KL Resch - BMJ 被引量: 2149发表: 1995年 Placebo effect in randomized, controlled studies of acute bipolar mania and depression...
In rigorous clinical trials, half the participants get the real medicine, while the rest get fake treatments in the form of sugar pills that look and taste the same – these should invoke the same placebo effect, but not the drug’s biological effect. Trials of new operating techniques should...
Since QoL assessments are generally performed on self-administered questionnaires, QoL endpoints are more prone to a placebo effect than traditional clinical endpoints. The placebo effect is a well-documented phenomenon in clinical trials, which has led to dramatic consequences on the clinical ...
The placebo effect is the beneficial outcome caused by a treatment that is not attributable to the pharmacological properties of the treament itself. This effect occurs if, for example, individuals taking pills with no active pharmacological agent have improved health outcomes compared with those taking...
摘要: Placebo effect in double-blind clinical trials: a review of interactions with medications. By - J. Kleijnen MD, A.J.M. de Craen MSc, J. van Everdingen MD, Prof L. Krol MD关键词: IODINE RADIOISOTOPES GOITER, NODULAR AGED SURGERY, OPERATIVE LEVOTHYROXINE DOI: 10.1016/S0140-6736(94...
Expectations and the placebo effect in clinical drug trials: Why we should not turn a blind eye to unblinding, and other cautionary notes Expectations and the placebo effect in clinical drug trials: Why we should not turn a blind eye to unblinding, and other cautionary notes. Clin. ... LC...
Double-blind, placebo-controlled (DBPC) trials are the gold standard for demonstrating clinical efficacy and tolerability. The placebo effect, although an important feature in placebo-controlled studies, has never been systematically investigated in allergen-specific immunotherapy (SIT) studies. This study...
There is significant and important drug*placebo interaction effect that may bias conventionally estimated drug effect. ClinicalTrial.gov identifier:NCT01501591(registered December 25, 2011). 展开 关键词: Balanced placebo design Randomized placebo-controlled trials Biased drug effect size Drug placebo ...